Nuguru Surya P, Rachakonda Sriker, Sripathi Shravani, Khan Mashal I, Patel Naomi, Meda Roja T
Internal Medicine, Kamineni Academy of Medical Sciences and Research Center, Hyderabad, IND.
Surgery, Bogomolets National Medical University, Kyiv, UKR.
Cureus. 2022 Aug 20;14(8):e28201. doi: 10.7759/cureus.28201. eCollection 2022 Aug.
There has been an established relationship between hypothyroidism and depression. Studies have demonstrated that somatostatin and serotonin influence the hypothalamus-pituitary-thyroid axis, which links hypothyroidism to depression. Multiple studies concluded that undiagnosed, untreated, undertreated patients with hypothyroidism are at increased risk of developing depression. Autoimmune thyroiditis is also associated with an increased risk of depression. Elevated thyroid-stimulating hormone (TSH), antithyroglobulin (TgAb), and thyroid peroxidase antibodies (TPOAb) levels have all been linked to depression and an increased risk of suicide. Moreover, hypothyroidism is known to be one of the leading causes of treatment-resistant depression. Treating underlying hypothyroidism with thyroid replacement therapy could significantly improve mood disorders such as depression. Levothyroxine therapy is also used as adjunctive therapy to antidepressants in the management of depression, and it is known to improve the symptoms of depression rapidly when compared to antidepressants alone. This review strengthens the link between hypothyroidism and depression, and it also demonstrates how treating the underlying hypothyroidism in people who have been diagnosed with depression will be very beneficial.
甲状腺功能减退与抑郁症之间已确立了一种关联。研究表明，生长抑素和血清素会影响下丘脑 - 垂体 - 甲状腺轴，这将甲状腺功能减退与抑郁症联系起来。多项研究得出结论，未被诊断、未接受治疗或治疗不足的甲状腺功能减退患者患抑郁症的风险增加。自身免疫性甲状腺炎也与抑郁症风险增加有关。促甲状腺激素（TSH）、抗甲状腺球蛋白（TgAb）和甲状腺过氧化物酶抗体（TPOAb）水平升高均与抑郁症及自杀风险增加有关。此外，甲状腺功能减退是难治性抑郁症的主要原因之一。用甲状腺替代疗法治疗潜在的甲状腺功能减退可显著改善诸如抑郁症等情绪障碍。左甲状腺素疗法在抑郁症管理中也用作抗抑郁药的辅助疗法，并且已知与单独使用抗抑郁药相比，它能迅速改善抑郁症症状。这篇综述强化了甲状腺功能减退与抑郁症之间的联系，并且还表明治疗已被诊断患有抑郁症的人的潜在甲状腺功能减退将非常有益。
