在HIV单一感染中，较高水平的血浆饱和脂肪酸与肝纤维化显著相关：一项病例对照研究。

Higher levels of plasmatic saturated fatty acid were significantly associated with liver fibrosis in HIV mono-infection: A case-control study.

作者信息

Almeida Cristiane Fonseca de, Arantes Ferreira Peres Wilza, Silva Paula Simplício da, Santos de Aguiar Cardoso Claudia, de Andrade Michelle Morata, Castro-Alves Julio, de Souza Borges Quintana Marcel, Araujo Marina Campos, Fraga Karla Yasmin Dias, Cormack Julliana Antunes, Moreira Ronaldo Ismerio, Cardoso Sandra W, Veloso Valdilea G, Grinsztejn Beatriz, Brito Patricia Dias de, Perazzo Hugo

机构信息

Grupo de Pesquisa Clínica em Nutrição e Doenças Infecciosas (GPClin_Nut), Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz (INI-FIOCRUZ), 21040-360, Rio de Janeiro, Brazil.

Serviço de Nutrição (SENUT), Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz (INI-FIOCRUZ), 21040-360, Rio de Janeiro, Brazil.

出版信息

Metabol Open. 2024 Nov 29;24:100334. doi: 10.1016/j.metop.2024.100334. eCollection 2024 Dec.

DOI:10.1016/j.metop.2024.100334

PMID:39717737

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11664064/

Abstract

BACKGROUND

The relationship between plasmatic fatty acid (FA) composition and liver fibrosis remains scarce in people living with HIV/AIDS (PLWHA). We aimed to evaluate the association of plasmatic FAs and liver fibrosis in HIV mono-infected individuals.

METHODS

This case-control study included PLWHA with liver fibrosis (cases) and randomly selected subjects without fibrosis (controls) from the PROSPEC-HIV study (NCT02542020). Participants with viral hepatitis, abusive alcohol consumption and lipid supplements use were excluded. Liver fibrosis was defined using transient elastography (TE) by liver stiffness measurement (LSM) ≥ 7.1 kPa or ≥ 6.2 kPa with M or XL probe, respectively. All HIV mono-infected participants with liver fibrosis identified at the baseline PROSPEC-HIV visit were included. Controls (1:1) were randomly selected among those HIV mono-infected participants without liver fibrosis. Plasmatic FA profile, dietary lipid intake, anthropometric measures, and blood samples were assessed. Plasmatic fatty acid was analyzed using gas chromatography and intake of fats lipids were assessed by two 24-h dietary recall (24-HDR). Multivariate logistic regression models adjusted by age, sex at birth and duration of antiretroviral therapy (ART) were performed.

RESULTS

A total of 142 participants (71 cases and 71 controls) [62 % female, median age = 46 (IQR, 37-53) years, 14.8 % with diabetes, median CD4 count = 655 cells/mm3, 96.5 % under ART] were included. Higher percentages of plasmatic palmitc acid (16:0) and saturated fatty acids (SFA) were observed in participants with liver fibrosis (cases) compared to those without (controls). Presence of higher percentage of plasmatic palmitc acid (16:0) was associated with an increased odds for liver fibrosis [adjusted OR = 1.23 (95%CI 1.04-1.46); p = 0.02] in multivariate models.

CONCLUSION

This study showed the potential role of the plasmatic FA composition in the pathogenesis of liver fibrosis in PLWHA.

摘要

背景

在人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）感染者（PLWHA）中，血浆脂肪酸（FA）组成与肝纤维化之间的关系仍然鲜有研究。我们旨在评估HIV单感染个体中血浆脂肪酸与肝纤维化的关联。

方法

本病例对照研究纳入了来自PROSPEC-HIV研究（NCT02542020）的伴有肝纤维化的PLWHA（病例组）和随机选择的无纤维化受试者（对照组）。排除患有病毒性肝炎、酗酒和使用脂质补充剂的参与者。肝纤维化通过瞬时弹性成像（TE）定义，分别使用肝脏硬度测量（LSM）≥7.1 kPa（使用M探头）或≥6.2 kPa（使用XL探头）。纳入所有在PROSPEC-HIV研究基线访视时确定的患有肝纤维化的HIV单感染参与者。对照组（1:1）从那些无肝纤维化的HIV单感染参与者中随机选择。评估血浆脂肪酸谱、饮食脂质摄入、人体测量指标和血样。使用气相色谱法分析血浆脂肪酸，并通过两次24小时饮食回顾（24-HDR）评估脂肪摄入。进行了按年龄、出生性别和抗逆转录病毒治疗（ART）持续时间调整的多变量逻辑回归模型分析。

结果

共纳入142名参与者（71例病例和71名对照）[62%为女性，中位年龄 = 46（四分位间距，37 - 53）岁，14.8%患有糖尿病，中位CD4细胞计数 = 655个细胞/mm³，96.5%接受ART治疗]。与无肝纤维化的参与者（对照组）相比，肝纤维化参与者（病例组）中血浆棕榈酸（16:0）和饱和脂肪酸（SFA）的百分比更高。在多变量模型中，血浆棕榈酸（16:0）百分比升高与肝纤维化几率增加相关[调整后的比值比 = 1.23（95%置信区间1.04 - 1.46）；p = 0.02]。