Suppr超能文献

在生命起源中,器官先于生物体出现吗?

Did organs precede organisms in the origin of life?

作者信息

Baquero Fernando, Bever Gabriel S, de Lorenzo Victor, Fernández-Lanza Val, Briones Carlos

机构信息

Division of Biology and Evolution of Microorganisms, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.

Network Medical Research Center for Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.

出版信息

Microlife. 2024 Dec 23;5:uqae025. doi: 10.1093/femsml/uqae025. eCollection 2024.

Abstract

Evolutionary processes acting on populations of organized molecules preceded the origin of living organisms. These prebiotic entities were independently and repeatedly produced [i.e. (re)-produced] by the assembly of their components, following an iterative process giving rise to nearly but not fully identical replicas, allowing for a prebiotic form of Darwinian evolution. Natural selection favored the more persistent assemblies, some possibly modifying their own internal structure, or even their environment, thereby acquiring function. We refer to these assemblies as proto-organs. In association with other assemblies (e.g. in a coacervate or encapsulated within a vesicle), such proto-organs could evolve and acquire a role within the collective when their coexistence favored the selection of the ensemble. Along millions of years, an extraordinarily small number of successful combinations of those proto-organs co-occurring in spatially individualizing compartments might have co-evolved forming a proto-metabolic and proto-genetic informative network, eventually leading to the selfreplication of a very few. Thus, interactions between encapsulated proto-organs would have had a much higher probability of evolving into proto-organisms than interactions among simpler molecules. Multimolecular forms evolve functions; thus, functional organs would have preceded organisms.

摘要

作用于有组织分子群体的进化过程先于生物体的起源。这些益生元实体通过其组成部分的组装而独立且反复地产生[即(重新)产生],遵循一个迭代过程,产生几乎但并非完全相同的复制品,从而实现了达尔文式进化的益生元形式。自然选择青睐更持久的组装体,其中一些可能会改变自身的内部结构,甚至改变其环境,从而获得功能。我们将这些组装体称为原器官。与其他组装体结合(例如在凝聚层中或包裹在囊泡内),当这些原器官的共存有利于整体的选择时,它们可以在集体中进化并发挥作用。在数百万年的时间里,在空间上个体化的隔室中同时出现的极少数成功的原器官组合可能共同进化,形成了一个原代谢和原遗传信息网络,最终导致极少数的自我复制。因此,与更简单分子之间的相互作用相比,被包裹的原器官之间的相互作用演变成原生物体的可能性要高得多。多分子形式进化出功能;因此,功能性器官先于生物体出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/11664216/8b5c9dc7c3c1/uqae025fig1.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验