Narisawa T, Sano M, Sato M, Takahashi T, Tanida N, Shimoyama T
Dis Colon Rectum. 1985 Jan;28(1):27-30. doi: 10.1007/BF02553902.
The relationship between cholecystectomy and large-bowel cancer development was investigated in animal models. Female ICR mice underwent cholecystectomy, and received 15 weekly intragastric administrations (Experiment 1) or 10 weekly subcutaneous injections (Experiment 2) of 15 mg/kg body weight of large-bowel carcinogen 1,2-dimethylhydrazine (DMH). Autopsy at 28 weeks after surgery showed that cholecystectomized mice had a nonsignificantly increased incidence of large-bowel carcinomas, compared to sham-operated and/or unoperated control mice (85 vs. 64 percent in Experiment 1; 31 vs. 16 and 20 percent in Experiment 2). Cholecystectomy alone without DMH treatment did not produce any cancer. Cholecystectomized mice excreted a significantly increased level of primary bile acids but an unchanged level of secondary bile acids in the feces, compared with unoperated control mice. It is obvious that cholecystectomy enhanced the development of DMH-induced, large-bowel carcinomas along with the change of fecal bile acid composition, suggesting that changes of bile acid metabolism after cholecystectomy may enhance or promote large-bowel carcinogenesis in man as well. This association of cholecystectomy and large-bowel cancer is not a strong one, however, as presented in epidemiologic as well as experimental studies.
在动物模型中研究了胆囊切除术与大肠癌发生之间的关系。雌性ICR小鼠接受胆囊切除术，并每周接受15次（实验1）或10次（实验2）胃内给药，剂量为15mg/kg体重的大肠致癌物1,2-二甲基肼（DMH）。术后28周尸检显示，与假手术和/或未手术的对照小鼠相比，胆囊切除小鼠的大肠癌发病率有非显著性增加（实验1中为85%对64%；实验2中为31%对16%和20%）。仅行胆囊切除术而未接受DMH治疗未产生任何癌症。与未手术的对照小鼠相比，胆囊切除小鼠粪便中初级胆汁酸水平显著升高，但次级胆汁酸水平未改变。显然，胆囊切除术随着粪便胆汁酸组成的变化增强了DMH诱导的大肠癌的发生，提示胆囊切除术后胆汁酸代谢的改变也可能增强或促进人类的大肠癌发生。然而，正如流行病学和实验研究所示，胆囊切除术与大肠癌之间的这种关联并不强烈。
