慢性阻塞性肺疾病患者肌肉萎缩与死亡风险之间的关联：一项系统评价
Association between muscular atrophy and mortality risk in patients with COPD: a systematic review.
作者信息
Li Wenyan, Wu Ying, Yang Xun, Zhu Jing, Feng Mei, Deng Rong, Yang Cui, Sun Chengcheng
机构信息
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241304626. doi: 10.1177/17534666241304626.
BACKGROUND
Muscular atrophy often can be seen at the end of stage in many chronic diseases. It will also negatively influence patients' outcomes. Different studies showed that the association between muscular atrophy and mortality in patients with chronic obstructive pulmonary disease (COPD) was unclear. This study will continue to assess the influence of muscular atrophy on mortality in patients with COPD.
OBJECTIVES
To systematically evaluate the association between muscular atrophy and death in patients with COPD.
DESIGN
Systematic review.
METHODS AND DATA SOURCES
A systematic review and meta-analysis was conducted. Databases including PubMed, Web of Science, Embase, the Cochrane Library, the China Biomedical Literature Service System, China Biomedical Literature Service System (CINAHL), China National Knowledge Infrastructure, the Wanfang database, and the WeiPu (VIP) were systematically searched for cohort studies on muscular atrophy and COPD from inception to July 1st, 2023. Two reviewers independently review, assess, and extract data from the included studies. Meta-analysis was performed using RevMan 5.4 software.
RESULTS
Thirteen cohort studies were ultimately included, involving 10,528 patients with COPD. There were seven cohort studies included in the meta-analysis, including 3,458 COPD patients. The meta-analysis showed that patients with COPD combined with muscular atrophy had a higher mortality risk (HR = 2.20, 95%CI (1.74, 2.79), < 0.00001). At the same time, patients with COPD who had muscular atrophy may had longer hospital stays.
CONCLUSION
Muscular atrophy is associated with the mortality and disease prognosis of patients with COPD. The conclusion needs to be supported and validated by more high-quality studies given the limitation of the number of articles included in this study.
TRIAL REGISTRATION
This systematic review protocol was prospectively registered with PROSPERO (No. CRD42024589435).
背景
在许多慢性疾病的终末期常可见肌肉萎缩。它也会对患者的预后产生负面影响。不同研究表明，慢性阻塞性肺疾病（COPD）患者中肌肉萎缩与死亡率之间的关联尚不清楚。本研究将继续评估肌肉萎缩对COPD患者死亡率的影响。
目的
系统评价COPD患者中肌肉萎缩与死亡之间的关联。
设计
系统综述。
方法和数据来源
进行了一项系统综述和荟萃分析。系统检索了包括PubMed、科学网、Embase、Cochrane图书馆、中国生物医学文献服务系统、护理学与健康领域数据库（CINAHL）、中国知网、万方数据库和维普（VIP）在内的数据库，以查找从建库至2023年7月1日关于肌肉萎缩与COPD的队列研究。两名研究者独立对纳入研究进行审查、评估并提取数据。使用RevMan 5.4软件进行荟萃分析。
结果
最终纳入13项队列研究，涉及10528例COPD患者。荟萃分析纳入了7项队列研究，包括3458例COPD患者。荟萃分析显示，合并肌肉萎缩的COPD患者死亡风险更高（HR = 2.20，95%CI（1.74，2.79），P < 0.00001）。同时，存在肌肉萎缩的COPD患者住院时间可能更长。
结论
肌肉萎缩与COPD患者的死亡率及疾病预后相关。鉴于本研究纳入文章数量有限，该结论需要更多高质量研究的支持和验证。
试验注册
本系统综述方案已在国际前瞻性系统综述注册库（PROSPERO）前瞻性注册（注册号：CRD42024589435）。
Zotero 插件