Zheng Hong-Yan, Zhang Hao-Yu, Wu Kuang-Hao, Cai Wen-Jie, Li Zhou-Zhou, Song Xin-Yu
Department of Respiratory and Critical Care Medicine, the First College of Clinical Medicine Science, Chinaaq , Three Gorges University, Yichang, 443003, People's Republic of China.
Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital, Yichang, 443003, People's Republic of China.
Syst Rev. 2025 Mar 11;14(1):58. doi: 10.1186/s13643-025-02801-7.
COPD patients suffering from malnutrition or sarcopenia often incur higher healthcare costs and experience adverse clinical outcomes. Despite this, the effectiveness of nutrient supplements in this population remains uncertain.
Two reviewers will independently search seven databases-PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Literature Database, and the Cochrane Library-for randomized controlled trials (RCTs) published before August 31, 2024. These RCTs should compare the effects of nutrient supplements against either a standard diet or placebo supplements in patients with COPD. The risk of bias in the included studies will be evaluated using the modified Jadad scale and the Cochrane Collaboration's risk of bias tool. Data synthesis will be conducted using RevMan software. Trial sequential analysis (TSA) will be applied to the primary outcomes. Additionally, subgroup and sensitivity analyses will be performed to assess the robustness of the findings.
Ethical approval is not required because this study is a secondary analysis of existing data. We will disseminate the findings through peer- reviewed publications.
CRD42024585694.
This systematic review and meta-analysis provides a thorough assessment of the efficacy of nutrient supplements in COPD patients, covering a wide range of studies. ·The use of the modified Jadad scale and the Cochrane Collaboration's risk of bias tool ensures a robust evaluation of study quality. Additionally, trial sequential analysis and subgroup analyses are employed to enhance the robustness of the findings. ·The credibility of the evidence may be compromised due to the potential for uncertain study quality and limited sample sizes in some included trials.
患有营养不良或肌肉减少症的慢性阻塞性肺疾病（COPD）患者往往会产生更高的医疗费用，并经历不良的临床结局。尽管如此，营养补充剂在该人群中的有效性仍不确定。
两名综述作者将独立检索七个数据库——PubMed、Embase、Web of Science、中国知网、万方、中国生物医学文献数据库和Cochrane图书馆——以获取2024年8月31日前发表的随机对照试验（RCT）。这些RCT应比较营养补充剂与标准饮食或安慰剂补充剂对COPD患者的影响。将使用改良的Jadad量表和Cochrane协作网的偏倚风险工具评估纳入研究的偏倚风险。将使用RevMan软件进行数据合成。试验序贯分析（TSA）将应用于主要结局。此外，将进行亚组分析和敏感性分析以评估研究结果的稳健性。
由于本研究是对现有数据的二次分析，因此无需伦理批准。我们将通过同行评审出版物传播研究结果。
CRD42024585694。
本系统评价和荟萃分析全面评估了营养补充剂对COPD患者的疗效，涵盖了广泛的研究。·使用改良的Jadad量表和Cochrane协作网的偏倚风险工具可确保对研究质量进行稳健评估。此外，采用试验序贯分析和亚组分析来增强研究结果的稳健性。·由于某些纳入试验的研究质量可能不确定且样本量有限，证据的可信度可能会受到影响。
