Becker Sarah L, Vague Morgan, Ortega-Loayza Alex G
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
J Invest Dermatol. 2025 Jun;145(6):1305-1322. doi: 10.1016/j.jid.2024.09.023. Epub 2024 Dec 24.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unclear etiology. Numerous theories of its underlying pathogenesis have been proposed, including external triggers, neutrophilic dysfunction, complement activation, and autoimmunity, as well as a possible component of underlying genetic susceptibility. This review seeks to synthesize current understanding of the pathogenesis of PG and integrate interactions between the multitude of implicated host immune pathways to guide and inform future directions into the treatment of PG.
坏疽性脓皮病（PG）是一种病因不明的嗜中性皮病。关于其潜在发病机制，已经提出了许多理论，包括外部触发因素、嗜中性粒细胞功能障碍、补体激活和自身免疫，以及潜在遗传易感性的可能因素。本综述旨在综合目前对PG发病机制的理解，并整合众多相关宿主免疫途径之间的相互作用，以指导并为未来PG的治疗方向提供信息。
