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坏疽性脓皮病发病机制与治疗的现状及未来展望

Current landscape and future perspectives in the pathogenesis and treatment of Pyoderma gangrenosum.

作者信息

Becker Sarah L, Ortega-Loayza Alex G

机构信息

Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.

Department of Dermatology, Oregon Health and Science University, Portland, OR, USA -

出版信息

Ital J Dermatol Venerol. 2025 Apr;160(2):145-154. doi: 10.23736/S2784-8671.24.08010-1. Epub 2024 Nov 29.

DOI:10.23736/S2784-8671.24.08010-1
PMID:39611420
Abstract

Pyoderma gangrenosum is a rare, ulcerative neutrophilic dermatosis of yet unknown origin. While advances have been made into the mechanisms underlying PG, our understanding is limited by a paucity of research and funding into this condition. This review highlights the current landscape of PG pathogenesis, diagnosis, and treatment in the hopes of encouraging additional scientific inquiry into this rare, severe condition.

摘要

坏疽性脓皮病是一种罕见的、溃疡性嗜中性皮肤病,病因尚不明确。尽管在坏疽性脓皮病的潜在机制方面已取得进展,但由于对这种疾病的研究和资金匮乏,我们的了解仍然有限。本综述重点介绍了坏疽性脓皮病发病机制、诊断和治疗的现状,希望能鼓励对这种罕见的严重疾病进行更多的科学探究。

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PLoS One. 2025 Jun 23;20(6):e0326203. doi: 10.1371/journal.pone.0326203. eCollection 2025.