定向随机性：在正确的位置构建生物分子凝聚物。
Directed stochasticity: Building biomolecular condensates in the right place.
作者信息
Geisler Mark S, Kemp James P, Duronio Robert J
机构信息
Curriculum in Genetics and Molecular Biology, University of North Carolina , Chapel Hill, NC, USA.
Integrative Program for Biological and Genome Sciences, University of North Carolina , Chapel Hill, NC, USA.
出版信息
J Cell Biol. 2025 Jan 6;224(1). doi: 10.1083/jcb.202412035. Epub 2024 Dec 24.
Controlling biomolecular condensate formation within the nucleus is critical for genome function. In this issue, Xu et al. (https://doi.org/10.1083/jcb.202401036) report that KPNA3 promotes histone locus body formation and expression of replication-dependent histone genes by both importing NPAT into the nucleus and preventing NPAT condensation from improperly occurring in the cytoplasm.
控制细胞核内生物分子凝聚物的形成对基因组功能至关重要。在本期杂志中，Xu等人（https://doi.org/10.1083/jcb.202401036）报道，KPNA3通过将NPAT导入细胞核并防止NPAT在细胞质中不当凝聚，促进组蛋白基因座体的形成和复制依赖性组蛋白基因的表达。
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