Wang Liangliang, Weichselbaum Ralph R, He Chuan
The Laboratory of Microbiome and Microecological Technology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637, USA.
RNA. 2025 Feb 19;31(3):395-401. doi: 10.1261/rna.080259.124.
Recent studies have revealed that the YTHDF family proteins bind preferentially to the -methyladenosine (mA)-modified mRNA and regulate the functions of these RNAs in different cell types. YTHDF2, the first identified mA reader in mammals, has garnered significant attention because of its profound effect to regulate the mA epitranscriptome in multiple biological processes. Here, we review current knowledge on the mechanisms by which YTHDF2 exerts its functions and discuss recent advances that underscore the multifaceted role of YTHDF2 in development, stem cell expansion, and immune evasion. We also highlight potential therapeutic interventions targeting the mA/YTHDF2 axis to improve the response to current antitumor therapies.
最近的研究表明，YTHDF家族蛋白优先结合N6-甲基腺苷（m⁶A）修饰的mRNA，并在不同细胞类型中调节这些RNA的功能。YTHDF2是哺乳动物中首个被鉴定出的m⁶A阅读蛋白，因其在多个生物学过程中对m⁶A表观转录组具有深远的调节作用而备受关注。在此，我们综述了目前关于YTHDF2发挥其功能的机制的知识，并讨论了强调YTHDF2在发育、干细胞扩增和免疫逃逸中多方面作用的最新进展。我们还强调了针对m⁶A/YTHDF2轴的潜在治疗干预措施，以改善对当前抗肿瘤治疗的反应。
