Andersson L C, Gahmberg C G, Teerenhovi L, Vuopio P
Int J Cancer. 1979 Dec 15;24(6):717-20. doi: 10.1002/ijc.2910240603.
We show here that the leukemic blast cells from three patients of a total of 15 subsequently diagnosed as having acute leukemia express on their surface the major red cell sialoglycoprotein, glycophorin A (GP-A). This was demonstrated (1) by indirect immunofluorescence using rabbit anti GP-A anti-serum and (2) by immune precipitation of GP-A from surface radiolabelled leukemic cells. Since GP-A is exclusively present on erythroid cells and their precursors, these findings indicate that a higher proportion of the blast leukemias than previously recognized show features of early erythroid differentiation.
我们在此表明，在总共15例随后被诊断为患有急性白血病的患者中，有3例患者的白血病原始细胞在其表面表达主要的红细胞唾液糖蛋白，即血型糖蛋白A（GP-A）。这一点通过以下方式得到证实：（1）使用兔抗GP-A抗血清进行间接免疫荧光检测，以及（2）从表面放射性标记的白血病细胞中免疫沉淀GP-A。由于GP-A仅存在于红系细胞及其前体细胞上，这些发现表明，与之前认识到的相比，更高比例的原始细胞白血病表现出早期红系分化的特征。
