Gao Yong-Chao, Zhou Ding-Ding, Lu Ye-Bin, Yang Li, Gong Xue-Jun, Chen Man-Yun, Liang Shuai, Huang Wei-Hua, Zhang Wei
Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China.
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 41008, China.
Heliyon. 2024 Dec 3;10(24):e40890. doi: 10.1016/j.heliyon.2024.e40890. eCollection 2024 Dec 30.
Recent studies have revealed that intratumoral microbiota is implicated in pancreatic cancer (PC), yet the spectra of intratumoral microbiota and their relationship with PC in Chinese patients remained to be clarified. In this study, tumor and paired paracancerous tissue from 53 patients were profiled by bacterial 16S rRNA gene sequencing. Both and -diversity displayed significant differences between tumors and adjacent tissues, with higher diversity in tumors. Three bacteria phyla (Proteobacteria, Firmicutes, and Actinobacteria) were prevalent in both cancers and adjacent normal tissues. A high prevalence of has been identified in the PC tumor microenvironment and was associated with prolonged overall survival. Furthermore, the results of experiments suggested that () could inhibit the proliferation and induce apoptosis of pancreatic cancer cells. These findings revealed distinctive microbial features of the PC tumors and normal tissues in Chinese populations and exhibited the antitumor potential of in PC.
最近的研究表明，肿瘤内微生物群与胰腺癌（PC）有关，但中国患者肿瘤内微生物群的谱及其与PC的关系仍有待阐明。在本研究中，通过细菌16S rRNA基因测序对53例患者的肿瘤组织和配对癌旁组织进行了分析。α多样性和β多样性在肿瘤组织和相邻组织之间均显示出显著差异，肿瘤组织中的多样性更高。三个细菌门（变形菌门、厚壁菌门和放线菌门）在癌组织和相邻正常组织中均普遍存在。已在PC肿瘤微环境中鉴定出高丰度的[具体细菌名称未给出]，且其与总生存期延长相关。此外，体外实验结果表明，[具体细菌名称未给出]（[细菌拉丁名未给出]）可抑制胰腺癌细胞的增殖并诱导其凋亡。这些发现揭示了中国人群中PC肿瘤组织和正常组织独特的微生物特征，并展示了[具体细菌名称未给出]在PC中的抗肿瘤潜力。
