Wang Yongjin, Wu Gangcheng, Wang Yandan, Xiao Feng, Yin Hongming, Yu Le, Shehzad Qayyum, Zhang Hui, Jin Qingzhe, Wang Xingguo
State Key Laboratory of Food Science and Resources, International Joint Research Laboratory for Lipid Nutrition and Safety, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Lipids. 2025 Mar;60(2):51-63. doi: 10.1002/lipd.12420. Epub 2024 Oct 13.
Pancreatic cancer (PC) is one of the most fatal malignancies, which has attracted scientists to investigate its etiology and pathogenesis. Nevertheless, the association between erythrocyte fatty acids and PC risk remains unclear. This study aimed to evaluate the association between levels of erythrocyte fatty acids and PC risk. The erythrocyte fatty acid compositions of 105 PC patients and 120 controls were determined by gas chromatography. Cases and controls were frequency matched by age and sex. Multivariable conditional logistic regression model and restricted cubic spline were applied to estimate the odds ratio with 95% confidence interval (OR, 95% CI) of erythrocyte fatty acids and PC risk. Our main findings indicated a significant negative association between levels of erythrocyte total monounsaturated fatty acids (MUFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of PC (OR = 0.30 [0.14, 0.63] and OR = 0.15 [0.06, 0.33], respectively). In contrast, erythrocyte n-6 polyunsaturated fatty acids, specifically linoleic acid (LA) and arachidonic acid (AA) levels, were positively associated with PC incidence (R = 4.24 [1.97, 9.46] and OR = 4.53 [2.09, 10.20]). Total saturated fatty acid (SFA), especially high levels of palmitic acid (16:0), was positively associated with the risk of PC (OR = 3.25 [1.53, 7.08]). Our findings suggest that levels of different types of fatty acids in erythrocytes may significantly alter PC susceptibility. Protective factors against PC include unsaturated fatty acids such as n-3 PUFA and MUFA.
胰腺癌（PC）是最致命的恶性肿瘤之一，这吸引了科学家们对其病因和发病机制进行研究。然而，红细胞脂肪酸与PC风险之间的关联仍不清楚。本研究旨在评估红细胞脂肪酸水平与PC风险之间的关联。通过气相色谱法测定了105例PC患者和120例对照者的红细胞脂肪酸组成。病例和对照按年龄和性别进行频率匹配。应用多变量条件逻辑回归模型和受限立方样条来估计红细胞脂肪酸与PC风险的比值比及95%置信区间（OR，95%CI）。我们的主要研究结果表明，红细胞总单不饱和脂肪酸（MUFA）和n-3多不饱和脂肪酸（n-3 PUFA）水平与PC风险之间存在显著负相关（OR分别为0.30[0.14，0.63]和OR为0.15[0.06，0.33]）。相比之下，红细胞n-6多不饱和脂肪酸，特别是亚油酸（LA）和花生四烯酸（AA）水平与PC发病率呈正相关（OR分别为4.24[1.97，9.46]和OR为4.53[2.09，10.20]）。总饱和脂肪酸（SFA），尤其是高水平的棕榈酸（16:0）与PC风险呈正相关（OR为3.25[1.53，7.08]）。我们的研究结果表明，红细胞中不同类型脂肪酸的水平可能会显著改变PC易感性。预防PC的保护因素包括n-3 PUFA和MUFA等不饱和脂肪酸。
