Kumashiro R, Piotrowski J J, Kholoussy A M, Hashimoto N, Matsumoto T
Eur Surg Res. 1985;17(1):44-52. doi: 10.1159/000128446.
Antiplatelet aggregators such as sulfinpyrazone (10 mg/kg), ticlopidine (200 mg/kg), and pyridine (0.1 mg/kg) significantly inhibited the degree of gastric ulceration in Sprague-Dawley rats subjected to cold restraint stress. The inhibition of platelet aggregation and that of microthrombus formation were evident in rats given antiplatelet aggregating drugs and exposed to cold stress. Therefore, platelet aggregation does play an important role in stress ulcer formation, and drugs which inhibit this aggregation should be given greater attention as to possible clinical application for treatment of stress ulcers.
抗血小板聚集剂，如磺吡酮（10毫克/千克）、噻氯匹定（200毫克/千克）和吡啶（0.1毫克/千克），可显著抑制遭受冷束缚应激的斯普拉格-道利大鼠的胃溃疡程度。给予抗血小板聚集药物并暴露于冷应激的大鼠中，血小板聚集和微血栓形成的抑制作用明显。因此，血小板聚集在应激性溃疡形成中确实起重要作用，抑制这种聚集的药物在治疗应激性溃疡的可能临床应用方面应受到更多关注。
