Piotrowski J J, Kumashiro R, Pushkarewicz M J, Kholoussy A M, Kuwano H, Matsumoto T
Int Surg. 1985 Apr-Jun;70(2):109-13.
The effect of pyridine in the prevention of cold restraint-induced stress ulcers in rats was investigated. After fasting, rats were administered the appropriate dosage of pyridine and were promptly placed into stress cages for cold room stress. The rats were sacrificed and bleeding, ulceration and vascular patency were examined. At doses of 0.01 mg/kg and 0.20 mg/kg, pyridine significantly decreased the amount of gastric hemorrhage and ulceration (p less than 0.01), as compared with the controls. In addition, microvascular dye, injected after stress, revealed perfused mucosal capillaries in the pyridine group, and occlusion of mucosal capillaries in the control group. These results suggest that the antiplatelet effect of pyridine reduced thrombus formation in the mucosal capillaries with subsequent reduction in mucosal ulceration.
研究了吡啶对预防大鼠冷束缚应激性溃疡的作用。禁食后，给大鼠施用适当剂量的吡啶，然后立即将其放入应激笼中进行冷室应激。处死大鼠后，检查出血、溃疡和血管通畅情况。与对照组相比，剂量为0.01mg/kg和0.20mg/kg的吡啶显著减少了胃出血和溃疡的数量（p<0.01）。此外，应激后注射微血管染料显示，吡啶组的黏膜毛细血管有灌注，而对照组的黏膜毛细血管闭塞。这些结果表明，吡啶的抗血小板作用减少了黏膜毛细血管中的血栓形成，从而减少了黏膜溃疡。
