Sharma Ishani, Padmanabhan Anup
Department of Biology, Trivedi School of Biosciences, Ashoka University, No. 2 Rajiv Gandhi Educational City, Sonipat, Haryana 131029, India.
BBA Adv. 2024 Nov 30;6:100127. doi: 10.1016/j.bbadva.2024.100127. eCollection 2024.
Biochemical signaling arising from mechanical force-induced physical changes in biological macromolecules is a critical determinant of key physiological processes across all biological lengths and time scales. Recent studies have deepened our understanding of how mechano-transduction regulates somatic tissues such as those in alveolar, gastrointestinal, embryonic, and skeleto-muscular systems. The germline of an organism has a heterogeneous composition - of germ cells at different stages of maturation and mature gametes, often supported and influenced by their accessory somatic tissues. While biochemical signaling underlying germline functioning has been extensively investigated, a deeper interest in their mechanical regulation has been gaining traction in recent years. In this review, we delve into the myriad ways in which germ cell development, maintenance, and functions are regulated by mechanical forces.
由机械力诱导生物大分子发生物理变化而产生的生化信号，是所有生物长度和时间尺度上关键生理过程的关键决定因素。最近的研究加深了我们对机械转导如何调节体细胞组织（如肺泡、胃肠道、胚胎和骨骼肌肉系统中的组织）的理解。生物体的生殖系具有异质组成——处于不同成熟阶段的生殖细胞和成熟配子，它们通常受到其附属体细胞组织的支持和影响。虽然生殖系功能背后的生化信号已得到广泛研究，但近年来人们对其机械调节的兴趣日益浓厚。在这篇综述中，我们深入探讨了机械力调节生殖细胞发育、维持和功能的多种方式。
