Mechano-regulation of germline development, maintenance, and differentiation.

Biochemical signaling arising from mechanical force-induced physical changes in biological macromolecules is a critical determinant of key physiological processes across all biological lengths and time scales. Recent studies have deepened our understanding of how mechano-transduction regulates somatic tissues such as those in alveolar, gastrointestinal, embryonic, and skeleto-muscular systems. The germline of an organism has a heterogeneous composition - of germ cells at different stages of maturation and mature gametes, often supported and influenced by their accessory somatic tissues. While biochemical signaling underlying germline functioning has been extensively investigated, a deeper interest in their mechanical regulation has been gaining traction in recent years. In this review, we delve into the myriad ways in which germ cell development, maintenance, and functions are regulated by mechanical forces.