Pauwels R, Van Der Straeten M, Weyne J, Bazin H
Eur J Respir Dis. 1985 Feb;66(2):98-104.
Two bronchoconstrictory agents, serotonin (5 HT) and carbachol, were investigated in different inbred rat strains in order to delineate possible factors influencing the bronchial reactivity. The challenge was given intravenously and a single dose was given to an individual animal. Inbred strains of rats differed significantly from each other in their reactivity to 5 HT and to carbachol. IC rats were good reactors to both 5 HT and carbachol. RA rats were intermediate reactors to both agents. OM/N rats had a good reaction to 5 HT, but showed only a minor bronchoconstriction after carbachol. BN and LE rats were poor reactors to both agents. The strain reactivities to the 2 provocation agents were not related. Breeding studies, using a good reactor, IC, and a poor reactor, DA strain, showed that the bronchial reactivity to 5 HT was inherited with a pattern that fitted with the autosomal recessive way of inheritance, high reactivity being recessive.
为了确定影响支气管反应性的可能因素，研究了两种支气管收缩剂，即血清素（5-羟色胺，5 HT）和卡巴胆碱，在不同近交系大鼠中的作用。采用静脉注射激发，每只动物给予单剂量。不同近交系大鼠对5 HT和卡巴胆碱的反应性存在显著差异。IC大鼠对5 HT和卡巴胆碱都是高反应者。RA大鼠对两种药物都是中等反应者。OM/N大鼠对5 HT反应良好，但注射卡巴胆碱后仅表现出轻微的支气管收缩。BN和LE大鼠对两种药物都是低反应者。不同品系对这两种激发剂的反应性没有相关性。用高反应性的IC品系和低反应性的DA品系进行繁殖研究表明，对5 HT的支气管反应性是以符合常染色体隐性遗传方式的模式遗传的，高反应性为隐性。
