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一种观点:疼痛管理中的神经轴治疗:现状与未来。

A perspective: neuraxial therapeutics in pain management: now and future.

作者信息

DeAndres Jose, Dickenson Anthony H, Hayek Salim, Linninger Andreas, Yaksh Tony L

机构信息

Department of Anesthesia, Valencia University School of Medicine, Valencia, Spain.

Departments of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

出版信息

Front Pain Res (Lausanne). 2024 Dec 10;5:1505019. doi: 10.3389/fpain.2024.1505019. eCollection 2024.

DOI:10.3389/fpain.2024.1505019
PMID:39720319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11666549/
Abstract

The neuraxial delivery of drugs for the management of pain and other spinal pathologies is widely employed and is the subject of a large volume of ongoing research with several thousand papers appearing in the past 5 years alone on neuraxial delivery. Several learned texts have been recently published. A number of considerations have contributed to this widespread interest in the development of the use of neuraxial therapeutics to manage pain. In the following section, major topics relevant to spinal encoding and in the use of neuraxial therapeutics are considered by the Frontiers in Pain Research editors of the research topic: ". This paper seeks to serve as a perspective to encourage the submission of manuscripts reflecting research in this exciting area.

摘要

通过神经轴给药来治疗疼痛和其他脊柱疾病的方法被广泛应用,并且是大量正在进行的研究的主题,仅在过去5年就有数千篇关于神经轴给药的论文发表。最近还出版了几本学术著作。有几个因素促成了人们对开发用于治疗疼痛的神经轴治疗方法的广泛兴趣。在以下部分,疼痛研究前沿研究主题的编辑们将探讨与脊柱编码及神经轴治疗方法应用相关的主要话题。本文旨在提供一个视角,鼓励提交反映这一令人兴奋领域研究的稿件。

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Parabrachial neurons promote nociplastic pain.臂旁核神经元促进病理性疼痛。
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Cordotomy for pain control and opioid reduction in cancer patients: A cancer center 11-year experience.癌症患者的疼痛控制和阿片类药物减量的脊髓切开术:一家癌症中心 11 年的经验。
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Chronic stress induces wide-spread hyperalgesia: The involvement of spinal CCK receptors.慢性应激诱导广泛的痛觉过敏:脊髓 CCK 受体的参与。
Neuropharmacology. 2024 Nov 1;258:110067. doi: 10.1016/j.neuropharm.2024.110067. Epub 2024 Jul 9.
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