Experimental Biology Unit, Department of Biomedicine, Faculty of Medicine of Porto, University of Porto, 4200-319, Porto, Portugal.
Institute for Research and Innovation in Health and IBMC, University of Porto, 4200-135, Porto, Portugal.
J Mol Med (Berl). 2024 Sep;102(9):1063-1088. doi: 10.1007/s00109-024-02464-2. Epub 2024 Jun 28.
Bone cancer pain (BCP) profoundly impacts patient's quality of life, demanding more effective pain management strategies. The aim of this systematic review was to investigate the role of inflammatory cytokines as potential molecular targets in BCP. A systematic search for animal rodent models of bone cancer pain studies was conducted in PubMed, Scopus, and Web of Science. Methodological quality and risk of bias were assessed using the SYRCLE RoB tool. Twenty-five articles met the inclusion criteria, comprising animal studies investigating molecular targets related to inflammatory cytokines in BCP. A low to moderate risk of bias was reported. Key findings in 23 manuscripts revealed upregulated classic pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-17, IL-18, IL-33) and chemokines in the spinal cord, periaqueductal gray, and dorsal root ganglia. Interventions targeting these cytokines consistently mitigated pain behaviors. Additionally, it was demonstrated that glial cells, due to their involvement in the release of inflammatory cytokines, emerged as significant contributors to BCP. This systematic review underscores the significance of inflammatory cytokines as potential molecular targets for alleviating BCP. It emphasizes the promise of targeted interventions and advocates for further research to translate these findings into effective therapeutic strategies. Ultimately, this approach holds the potential to enhance the patient's quality of life.
骨癌疼痛（BCP）严重影响患者的生活质量，需要更有效的疼痛管理策略。本系统评价旨在研究炎症细胞因子作为 BCP 潜在分子靶点的作用。在 PubMed、Scopus 和 Web of Science 中对骨癌疼痛动物啮齿动物模型的研究进行了系统搜索。使用 SYRCLE RoB 工具评估了方法学质量和偏倚风险。有 25 篇文章符合纳入标准，包括研究与 BCP 中炎症细胞因子相关的分子靶点的动物研究。报告的偏倚风险为低到中度。23 篇论文的主要发现表明，脊髓、导水管周围灰质和背根神经节中经典促炎细胞因子（TNF-α、IL-1β、IL-6、IL-17、IL-18、IL-33）和趋化因子上调。针对这些细胞因子的干预措施一致减轻了疼痛行为。此外，研究表明，由于炎症细胞因子的释放，神经胶质细胞是 BCP 的重要贡献者。本系统评价强调了炎症细胞因子作为缓解 BCP 的潜在分子靶点的重要性。它强调了靶向干预的前景，并主张进一步研究将这些发现转化为有效的治疗策略。最终，这种方法有可能提高患者的生活质量。
