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成人纯卵黄囊睾丸肿瘤：诊断难题

Pure Yolk Sac Testicular Tumour in an Adult: A Diagnostic Dilemma.

作者信息

Fonseka Thomas R, Adewole Charles, Mele Teresa, Goyal Anuj, Lee Wai Gin

机构信息

Urology, Royal Free Hospital, London, GBR.

Pathology, Royal Free Hospital, London, GBR.

出版信息

Cureus. 2024 Nov 24;16(11):e74332. doi: 10.7759/cureus.74332. eCollection 2024 Nov.

DOI:10.7759/cureus.74332
PMID:39720369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11667207/
Abstract

A rare case of a pure yolk sac testicular tumour presenting in an adult with learning difficulties is presented. Pure yolk sac tumours are much more common in children, but when they do occur in adults, onset can be both insidious and aggressive. The best practice for identification involves the precise use of ultrasound, blood tests for tumour markers and FDG-PET/CT imaging for staging. Dual-phase treatment in the form of radical inguinal orchidectomy performed expediently followed by chemotherapy is the mainstay of treatment in advanced cases.

摘要

本文报告了一例罕见的成人纯卵黄囊睾丸肿瘤病例，该患者伴有学习困难。纯卵黄囊肿瘤在儿童中更为常见，但在成人中发生时，起病可能隐匿且侵袭性强。最佳的确诊方法包括精确使用超声、进行肿瘤标志物血液检测以及采用FDG-PET/CT成像进行分期。对于晚期病例，主要治疗方法是先迅速进行根治性腹股沟睾丸切除术，随后进行化疗的双阶段治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d03/11667207/327f5f4a4bd4/cureus-0016-00000074332-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d03/11667207/b5dd3aa1f801/cureus-0016-00000074332-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d03/11667207/4a7f52b0110e/cureus-0016-00000074332-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d03/11667207/327f5f4a4bd4/cureus-0016-00000074332-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d03/11667207/b5dd3aa1f801/cureus-0016-00000074332-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d03/11667207/4a7f52b0110e/cureus-0016-00000074332-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d03/11667207/327f5f4a4bd4/cureus-0016-00000074332-i03.jpg

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本文引用的文献

1
Characteristics and outcomes of pediatric testicular yolk Sac tumor.小儿睾丸卵黄囊瘤的特征与转归
Front Pediatr. 2022 Dec 19;10:1024906. doi: 10.3389/fped.2022.1024906. eCollection 2022.
2
Pure post-pubertal yolk sac tumor of the testis: An extremely rare and aggressive entity.睾丸青春期后纯卵黄囊瘤：一种极其罕见且侵袭性强的实体瘤。
Ann Diagn Pathol. 2023 Apr;63:152086. doi: 10.1016/j.anndiagpath.2022.152086. Epub 2022 Dec 23.
3
A Rare Case of Post-pubertal Pure Yolk-sac Tumour Incidentally Diagnosed after Surgical Intervention for Fournier's Gangrene.
青春期后单纯卵黄囊瘤一例，偶然在 Fournier 坏疽手术干预后诊断。
J Coll Physicians Surg Pak. 2022 Aug;32(8):1073-1075. doi: 10.29271/jcpsp.2022.08.1073.
4
Worldwide Distribution, Risk Factors, and Temporal Trends of Testicular Cancer Incidence and Mortality: A Global Analysis.全球睾丸癌发病率和死亡率的分布、风险因素和时间趋势：全球分析。
Eur Urol Oncol. 2022 Oct;5(5):566-576. doi: 10.1016/j.euo.2022.06.009. Epub 2022 Jul 19.
5
Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.睾丸精原细胞瘤和非精原细胞瘤：ESMO-EURACAN诊断、治疗及随访临床实践指南
Ann Oncol. 2022 Apr;33(4):362-375. doi: 10.1016/j.annonc.2022.01.002. Epub 2022 Jan 19.
6
Late Testicular Yolk Sac Tumor With Cerebellar Metastasis and a Rapid Recurrence After a Gross Total Resection: A Case Report.晚期睾丸卵黄囊瘤伴小脑转移及全切除术后快速复发：1例报告
Cureus. 2021 Aug 13;13(8):e17143. doi: 10.7759/cureus.17143. eCollection 2021 Aug.
7
Pure yolk sac tumor of testis with lung metastasis in an adult patient - case report.成年男性睾丸纯卵黄囊瘤伴肺转移——病例报告
Med Pharm Rep. 2021 Apr;94(2):252-255. doi: 10.15386/mpr-1470. Epub 2021 Apr 29.
8
Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium.预测转移性非精原细胞瘤生殖细胞肿瘤（NSGCT）男性患者的结局：国际生殖细胞肿瘤协作组更新联盟的结果。
J Clin Oncol. 2021 May 10;39(14):1563-1574. doi: 10.1200/JCO.20.03296. Epub 2021 Apr 6.
9
18F-FDG PET/CT in pure testicular Yolk Sac Tumor in adult.18F-FDG PET/CT在成人单纯性睾丸卵黄囊瘤中的应用
Int Braz J Urol. 2021 Jan-Feb;47(1):202-204. doi: 10.1590/S1677-5538.IBJU.2019.0780.
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Do Learning Disabilities Affect Testicular Cancer Survival: A National Cohort Study Between 2001 and 2015.学习障碍是否影响睾丸癌生存：2001 年至 2015 年全国队列研究。
Eur Urol Oncol. 2020 Dec;3(6):773-779. doi: 10.1016/j.euo.2018.12.008. Epub 2019 Jan 15.