• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

病例报告:一名老年患者以味觉障碍为首发症状的抑郁症。

Case report: Depression in an older patient with dysgeusia as the initial symptom.

作者信息

Guo Longrun, He Zhufa

机构信息

Department of Rehabilitation Medicine, The Third People's Hospital of Ganzhou City, Ganzhou, Jiangxi, China.

Department of Psychiatry, The Third People's Hospital of Ganzhou City, Ganzhou, Jiangxi, China.

出版信息

Front Psychiatry. 2024 Dec 10;15:1478359. doi: 10.3389/fpsyt.2024.1478359. eCollection 2024.

DOI:10.3389/fpsyt.2024.1478359
PMID:39720431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11666477/
Abstract

INTRODUCTION

Depression is the most common mental illness among older adults, with substantial and persistent mood depression as the main clinical feature, which is unfavorable for improvement. The clinical manifestations can range from melancholy to grief or even numbness. Approximately one-third of older adult patients exhibit physical discomfort as the first symptom; dysgeusia as the first symptom, is very rare in clinical practice. Dysgeusia is a clinical symptom with no specific objective indicator; thus, the likelihood of misdiagnosis and missed diagnosis is high.

CASE PRESENTATION

In this study, a 60-year-old female housewife with elementary school as her highest level of education, presented to the outpatient department with dysgeusia, poor sleep, and poor mood persisting for >1 year, which aggravated 2 weeks before hospital visit. Psychiatric examination showed clear consciousness; the patient was cleanly and timely dressed and demonstrated self-care but had a worrisome expression. Using the diagnostic criteria of the International Classification of Diseases (10 edition), a diagnosis of a major depressive episode with psychotic symptoms was made. Following pharmacological and psychological treatment, the patient's condition improved. The patient was compliant to treatment (10 mg/day of escitalopram), had a stable mood, good sleep, and no dysgeusia at >2 years of follow-up as an outpatient. She was able to do housework and take care of her children normally and did not complain about any other issues.

CONCLUSION

Physical discomfort is a very common complaint in older patients with depression. If persistent physical symptoms do not improve after repeated medical treatment, timely assessment of the patient's mental state or psychiatric referral should be considered to diagnose geriatric depression. Timely pharmacological and psychological therapy are the preferred treatment for older adults.

摘要

引言

抑郁症是老年人中最常见的精神疾病,以显著而持久的心境低落为主要临床特征,不利于病情改善。临床表现可从忧郁到悲伤甚至麻木。约三分之一的老年患者以身体不适为首发症状;以味觉障碍为首发症状在临床实践中非常罕见。味觉障碍是一种无特定客观指标的临床症状;因此,误诊和漏诊的可能性很高。

病例介绍

在本研究中,一名60岁的家庭主妇,最高学历为小学,因味觉障碍、睡眠差和情绪低落持续超过1年就诊于门诊,入院前2周病情加重。精神检查显示意识清楚;患者穿着整洁及时,具备自理能力,但表情忧虑。根据国际疾病分类(第10版)的诊断标准,诊断为伴有精神病性症状的重度抑郁发作。经过药物和心理治疗,患者病情好转。患者依从治疗(艾司西酞普兰10毫克/天),在门诊随访2年多来情绪稳定、睡眠良好且无味觉障碍。她能够正常做家务和照顾孩子,未抱怨任何其他问题。

结论

身体不适是老年抑郁症患者非常常见的主诉。如果反复就医后持续性躯体症状仍未改善,应考虑及时评估患者的精神状态或转诊精神科以诊断老年抑郁症。及时的药物和心理治疗是老年人的首选治疗方法。

相似文献

1
Case report: Depression in an older patient with dysgeusia as the initial symptom.病例报告:一名老年患者以味觉障碍为首发症状的抑郁症。
Front Psychiatry. 2024 Dec 10;15:1478359. doi: 10.3389/fpsyt.2024.1478359. eCollection 2024.
2
Letter to the Editor: Depression As The First Symptom Of Frontal Lobe Grade 2 Malignant Glioma.给编辑的信:额颞叶 2 级恶性胶质瘤的首发症状为抑郁。
Turk Psikiyatri Derg. 2022 Summer;33(2):143-145. doi: 10.5080/u25957.
3
Letter to the Editor: CONVERGENCES AND DIVERGENCES IN THE ICD-11 VS. DSM-5 CLASSIFICATION OF MOOD DISORDERS.给编辑的信:《ICD-11 与 DSM-5 心境障碍分类的趋同与分歧》
Turk Psikiyatri Derg. 2021;32(4):293-295. doi: 10.5080/u26899.
4
Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.拔毛癖:一名11岁女孩的怪异脱发模式。
Acta Dermatovenerol Croat. 2016 Jun;24(2):150-3.
5
"Is It Her Hormones?": Psychiatric Diagnoses and Polycystic Ovarian Syndrome.“是她的激素问题吗?”:精神科诊断与多囊卵巢综合征
J Dev Behav Pediatr. 2016 Jan;37(1):103-4. doi: 10.1097/DBP.0000000000000243.
6
[Psychiatric manifestations of vitamin B12 deficiency: a case report].[维生素B12缺乏的精神症状:一例报告]
Encephale. 2003 Nov-Dec;29(6):560-5.
7
[Psychiatric manifestations of lupus erythematosus systemic and Sjogren's syndrome].[系统性红斑狼疮和干燥综合征的精神症状]
Encephale. 2001 Nov-Dec;27(6):588-99.
8
[A case of depression whose symptoms cured by setting her psychological base on the transcendent level].一例通过在超验层面建立心理基础而症状得以治愈的抑郁症病例
Seishin Shinkeigaku Zasshi. 2009;111(10):1203-11.
9
[Guidelines for the prevention and management of bronchial asthma (2024 edition)].[支气管哮喘防治指南(2024年版)]
Zhonghua Jie He He Hu Xi Za Zhi. 2025 Mar 12;48(3):208-248. doi: 10.3760/cma.j.cn112147-20241013-00601.
10
Can atypical dysgeusia in depression be related to a deafferentation syndrome?抑郁症中的非典型味觉障碍是否与传入神经阻滞综合征有关?
Med Hypotheses. 2020 Nov;144:110047. doi: 10.1016/j.mehy.2020.110047. Epub 2020 Jun 29.

本文引用的文献

1
Current trends and perspectives on salty and salt taste-enhancing peptides: A focus on preparation, evaluation and perception mechanisms of salt taste.咸肽和增强咸味肽的当前趋势和展望:聚焦于咸味感知机制、咸肽的制备和评价。
Food Res Int. 2024 Aug;190:114593. doi: 10.1016/j.foodres.2024.114593. Epub 2024 Jun 6.
2
Treatment-Resistant Depression in Older Adults.老年人的治疗抵抗性抑郁症。
N Engl J Med. 2024 Feb 15;390(7):630-639. doi: 10.1056/NEJMcp2305428.
3
Liking of salt is associated with depression, anxiety, and stress.人们对盐的喜好与抑郁、焦虑和压力有关。
Chem Senses. 2023 Jan 1;48. doi: 10.1093/chemse/bjad038.
4
Molecular and Cellular Mechanisms of Salt Taste.盐味的分子与细胞机制。
Annu Rev Physiol. 2023 Feb 10;85:25-45. doi: 10.1146/annurev-physiol-031522-075853. Epub 2022 Nov 4.
5
Salt taste threshold and contributory factors of chronic kidney disease patients: a cross-sectional study.慢性肾脏病患者的盐味阈值及相关因素:一项横断面研究。
Int Urol Nephrol. 2023 May;55(5):1211-1218. doi: 10.1007/s11255-022-03403-1. Epub 2022 Nov 1.
6
A Systematic Review of Salt Taste Function and Perception Impairments in Adults with Chronic Kidney Disease.一项关于慢性肾脏病成人盐味觉功能和感知障碍的系统评价。
Int J Environ Res Public Health. 2022 Oct 3;19(19):12632. doi: 10.3390/ijerph191912632.
7
Salt Taste, Nutrition, and Health.盐的味道、营养与健康。
Nutrients. 2020 May 25;12(5):1537. doi: 10.3390/nu12051537.
8
Salt Taste Sensitivity and Heart Failure Outcomes Following Heart Failure Hospitalization.盐味觉敏感度与心力衰竭住院后的心力衰竭结局。
Am J Cardiol. 2020 Jul 15;127:58-63. doi: 10.1016/j.amjcard.2020.04.008. Epub 2020 Apr 20.
9
Depression in Older Adults: A Treatable Medical Condition.老年人抑郁症:一种可治疗的医学病症。
Prim Care. 2017 Sep;44(3):499-510. doi: 10.1016/j.pop.2017.04.007. Epub 2017 Jul 18.
10
Depression and chronic pain in the elderly: links and management challenges.老年人的抑郁症与慢性疼痛:关联及管理挑战
Clin Interv Aging. 2017 Apr 21;12:709-720. doi: 10.2147/CIA.S113576. eCollection 2017.