苯巴比妥和2,3,7,8-四氯二苯并对二噁英对犬肝脏中2,3,7,8-四氯二苯并对二噁英代谢的影响。
Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog.
作者信息
Poiger H, Schlatter C
出版信息
Experientia. 1985 Mar 15;41(3):376-8. doi: 10.1007/BF02004514.
PMID:3972084
Abstract
The influence of phenobarbital and TCDD pretreatment on the formation and biliary excretion of TCDD-metabolites following single doses of 3H-TCDD was investigated. Without pretreatment, 24.5% of the absorbed 3H-TCDD dose was excreted in the bile within 110 h. Phenobarbital did not influence this rate, whereas a single dose of 10 micrograms of unlabeled TCDD/kg b.wt nine days earlier resulted in a doubling of the amount of radioactive material eliminated in the bile (47.4%).
摘要
研究了苯巴比妥和2,3,7,8-四氯二苯并-p-二恶英（TCDD）预处理对单次给予3H-TCDD后TCDD代谢产物的形成及胆汁排泄的影响。未经预处理时，在110小时内，吸收剂量的3H-TCDD中有24.5%经胆汁排泄。苯巴比妥不影响该排泄率，而提前九天单次给予10微克/千克体重的未标记TCDD导致胆汁中消除的放射性物质数量增加一倍（47.4%）。
Zotero 插件