哺乳动物2,3,7,8-四氯二苯并对二恶英代谢物的结构解析
Structure elucidation of mammalian TCDD-metabolites.
作者信息
Poiger H, Buser H R, Weber H, Zweifel U, Schlatter C
出版信息
Experientia. 1982 Apr 15;38(4):484-6. doi: 10.1007/BF01952652.
PMID:7084417
Abstract
Thin layer and gas chromatographic examination of the bile of dogs which were given tritium-labelled TCDD revealed the presence of several polar biotransformation products. The structure of 5 phenolic metabolites was elucidated by combined gas chromatography-mass spectrometry. A metabolic breakdown scheme for TCDD in the dog is proposed.
摘要
对给予氚标记的2,3,7,8-四氯二苯并对二恶英的犬胆汁进行薄层色谱和气相色谱检测，结果显示存在几种极性生物转化产物。通过气相色谱-质谱联用技术阐明了5种酚类代谢物的结构。提出了犬体内2,3,7,8-四氯二苯并对二恶英的代谢分解方案。
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