Liang Fuming, You Qing, Yu Bin, Wang Chen, Yang Yanlian, Zhu Ling, He Zhaohui
Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 1 Friendship Road, Chongqing, 400016, P. R. China.
CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Adv Sci (Weinh). 2025 Feb;12(7):e2409713. doi: 10.1002/advs.202409713. Epub 2024 Dec 25.
Survival quality of glioblastoma (GBM) patients remains undesirable despite the aggressive multimodal treatment methods implemented, which are strongly associated with tumor recurrence after surgical resection. Self-renewal and strong tumourigenic capacity of glioblastoma stem cells (GSCs) at the narrow margin of the incision are essential factors driving tumor secondary strikes. Currently, the challenges in treating postoperative residual GSCs are mainly due to the lack of materials for incision and GSCs targeting. In this study, a neurotransmitter-mimicking nanovesicle (PMVS-P) based on platelet membrane-derived vesicle (PMV) with anti-GSC drug salinomycin (SAL)-loading and polydopamine (PDA)-surface is synthesized. PMVS-P exhibits surgical incision targeting ability and specifically identified GSCs with highly expressed D2 dopamine receptor (D2DR), a central nervous system neurotransmitter receptor, thus suppressing GBM recurrence. This neurotransmitter-mimicking nanovesicle primed GSC-specific tumoricidal treatment with broadened applications for preventing tumor recurrence.
尽管实施了积极的多模式治疗方法，但胶质母细胞瘤（GBM）患者的生存质量仍然不理想，这些方法与手术切除后肿瘤复发密切相关。胶质母细胞瘤干细胞（GSCs）在切口边缘的自我更新和强大的致瘤能力是导致肿瘤二次侵袭的重要因素。目前，治疗术后残留GSCs的挑战主要在于缺乏针对切口和GSCs的材料。在本研究中，合成了一种基于血小板膜衍生囊泡（PMV）的神经递质模拟纳米囊泡（PMVS-P），其负载了抗GSC药物沙林霉素（SAL）并具有聚多巴胺（PDA）表面。PMVS-P具有手术切口靶向能力，并能特异性识别高表达D2多巴胺受体（D2DR，一种中枢神经系统神经递质受体）的GSCs，从而抑制GBM复发。这种神经递质模拟纳米囊泡引发了针对GSC的特异性杀瘤治疗，在预防肿瘤复发方面具有广泛的应用前景。
