Alam Khorshed, Hossain Md Sawkat, Zhao Yiming, Zhang Zhiheng, Xu Shouying, Hao Jinfang, Yang Qing, Li Aiying
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China; Bangladesh Standards and Testing Institution (BSTI), Dhaka 1208, Bangladesh.
Chittagong Medical College Hospital, K B Fazlul Kader Road, Panchlaish, Chattogram 4203, Bangladesh.
Bioorg Chem. 2025 Jan;154:108071. doi: 10.1016/j.bioorg.2024.108071. Epub 2024 Dec 16.
Tryptanthrin and its derivatives, representing a type of alkaloids with indoloquinazoline structures, were first obtained from blue plants and indigo, and then extracted from fungi, marine bacteria and a number of many other natural sources. Various strategies for their chemical synthesis have been reported while tryptanthrin biosynthesis has been less investigated. Tryptanthrin and its derivative products have a broad range of pharmacological and biological functions. In this review, we cover the sources, chemical synthesis and biosynthesis, modes of action and biological activities of tryptanthrin and its derivatives.
色胺酮及其衍生物是一类具有吲哚喹唑啉结构的生物碱，最初从蓝色植物和靛蓝中获得，随后从真菌、海洋细菌及许多其他天然来源中提取得到。虽然已有多种关于它们化学合成的策略报道，但色胺酮生物合成的研究较少。色胺酮及其衍生产品具有广泛的药理和生物学功能。在本综述中，我们涵盖了色胺酮及其衍生物的来源、化学合成与生物合成、作用模式及生物活性。
