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伴有多叶核形态的弥漫性大B细胞淋巴瘤，携带t(14;18)(q32;q21)和t(3;22)(q27;q11)

Diffuse Large B-cell Lymphoma with a Multilobated Nuclear Morphology Harboring t(14;18)(q32;q21) and t(3;22)(q27;q11).

作者信息

Manabe Masahiro, Inano Naoyuki, Hagiwara Yuuji, Koh Ki-Ryang

机构信息

Department of Hematology, Osaka General Hospital of West Japan Railway Company, Japan.

Department of Clinical Laboratory, Osaka General Hospital of West Japan Railway Company, Japan.

出版信息

Intern Med. 2025 Jul 15;64(14):2234-2239. doi: 10.2169/internalmedicine.4719-24. Epub 2024 Dec 26.

DOI:10.2169/internalmedicine.4719-24
PMID:39721682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12331281/
Abstract

A 70-year-old woman was admitted to our hospital with dyspnea. Atypical cells with multilobated nuclei were observed in the pleural effusion. Diffuse large B-cell lymphoma (DLBCL) was diagnosed based on a cell block analysis. A chromosomal analysis of lymphoma cells revealed t(14;18)(q32;q21) and t(3;22)(q27;q11). The patient's disease was refractory to chemotherapy, and she died within one year. Although flower-like nuclei are typical of adult T-cell lymphoma/leukemia, similar multilobated nuclei may occur in DLBCL. Although multilobated DCBCL have been reported to have a better prognosis than other forms of DLBCL, the abovementioned translocations may have contributed to the patient's aggressive clinical course.

摘要

一名70岁女性因呼吸困难入院。在胸腔积液中观察到具有多叶核的非典型细胞。基于细胞块分析诊断为弥漫性大B细胞淋巴瘤（DLBCL）。淋巴瘤细胞的染色体分析显示t(14;18)(q32;q21)和t(3;22)(q27;q11)。患者的疾病对化疗耐药，一年内死亡。虽然花状核是成人T细胞淋巴瘤/白血病的典型特征，但类似的多叶核也可能出现在DLBCL中。虽然据报道多叶核DLBCL的预后比其他形式的DLBCL更好，但上述易位可能导致了患者的侵袭性临床病程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/ea4003ffbcfe/1349-7235-64-14-2234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/72196118ce45/1349-7235-64-14-2234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/e599c8356200/1349-7235-64-14-2234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/0a225361ca99/1349-7235-64-14-2234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/ea4003ffbcfe/1349-7235-64-14-2234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/72196118ce45/1349-7235-64-14-2234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/e599c8356200/1349-7235-64-14-2234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/0a225361ca99/1349-7235-64-14-2234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab1/12331281/ea4003ffbcfe/1349-7235-64-14-2234-g004.jpg

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Blood Res. 2023 Dec 31;58(4):165. doi: 10.5045/br.2023.2023178. Epub 2023 Oct 19.
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