Sirera Rafael, Beltrán-Visiedo Manuel, Galluzzi Lorenzo
Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Biotechnology, Universitat Politècnica de València, Valencia, Spain; Unidad Mixta TRIAL, Centro Investigación Príncipe Felipe-Fundación Investigación, Hospital General Universitario de Valencia, Valencia, Spain; Centro de Investigación Biomédica en Red Cáncer, CIBERONC, Madrid, Spain.
Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Trends Pharmacol Sci. 2025 Feb;46(2):95-97. doi: 10.1016/j.tips.2024.12.001. Epub 2024 Dec 24.
Most solid tumors are insensitive to single-agent immunotherapy, calling for the development of combinatorial treatment regimens. Recently, Lin and collaborators developed a pharmacological platform enabling the combination of different immunotherapies into a single chemical entity. This approach may effectively circumvent obstacles associated with the simultaneous delivery of multiple immunotherapeutic agents.
大多数实体瘤对单药免疫疗法不敏感,这就需要开发联合治疗方案。最近,林及其合作者开发了一个药理学平台,能够将不同的免疫疗法组合成一个单一的化学实体。这种方法可能有效地规避与同时递送多种免疫治疗剂相关的障碍。