靶向癌症干细胞中的泛素蛋白酶体系统。
Targeting the ubiquitin proteasome system in cancer stem cells.
作者信息
Atta Hind, Kassem Dina H, Kamal Mohamed M, Hamdy Nadia M
机构信息
School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, Cairo, Egypt.
Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
出版信息
Trends Cell Biol. 2025 Feb;35(2):97-101. doi: 10.1016/j.tcb.2024.11.011. Epub 2024 Dec 24.
Over the past few years there has been an alarming burst of cancer burden worldwide. Cancer stem cells (CSCs) act as hidden devils within tumors, rendering cancer therapy a strenuous goal. Recently, the ubiquitin proteasome system (UPS) was proved to be an essential contributor to the CSC phenotype. This forum article aims to outline new strategies/technologies targeting UPS modulation in CSCs as a potential novel modality for efficient cancer therapy.
在过去几年中，全球癌症负担急剧增加，令人担忧。癌症干细胞（CSCs）就像肿瘤中的隐藏恶魔，使癌症治疗成为一项艰巨的目标。最近，泛素蛋白酶体系统（UPS）被证明是CSC表型的重要促成因素。这篇论坛文章旨在概述针对CSCs中UPS调节的新策略/技术，作为一种潜在的高效癌症治疗新方法。
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