血清学在诊断女性生殖道衣原体感染中的失效情况。
Failure of serology in diagnosing chlamydial infections of the female genital tract.
作者信息
Schachter J, Cles L, Ray R, Hines P A
出版信息
J Clin Microbiol. 1979 Nov;10(5):647-9. doi: 10.1128/jcm.10.5.647-649.1979.
Abstract
Chlamydia trachomatis was recoved from 20% (36/180) of women attending a venereal disease clinic. All infected women had chlamydial antibodies in their serum and cervical secretions. However, the background rates of chlamydial antibody in chlamydia-negative women were very high. Measurement of antibodies in serum (complement fixation or immunoglobulin G [IgG] and IgM by microimmunofluorescence) or cervical secretion (IgG, IgM, IgA or secretory IgA classes) did not result in predictive values of greater than 32%. It is concluded that the detection of chlamydial antibodies in serum or cervical secretions cannot be substituted for agent isolation in diagnosing these infections.
摘要
从一家性病诊所就诊的女性中，20%（36/180）检出沙眼衣原体。所有感染女性的血清和宫颈分泌物中均有衣原体抗体。然而，衣原体阴性女性中衣原体抗体的背景率非常高。检测血清中的抗体（补体结合试验或用微量免疫荧光法检测免疫球蛋白G[IgG]和IgM）或宫颈分泌物中的抗体（IgG、IgM、IgA或分泌型IgA类别），预测值均未超过32%。结论是，在诊断这些感染时，血清或宫颈分泌物中衣原体抗体的检测不能替代病原体分离。
相似文献
1
Failure of serology in diagnosing chlamydial infections of the female genital tract.
J Clin Microbiol. 1979 Nov;10(5):647-9. doi: 10.1128/jcm.10.5.647-649.1979.
2
Antibodies to Chlamydia trachomatis in cervicovaginal secretions: relation to serum antibodies and current chlamydial infection.
Sex Transm Dis. 1980 Jan-Mar;7(1):11-5. doi: 10.1097/00007435-198001000-00003.
3
Rapid diagnosis of chlamydial infection of the cervix.
Br J Vener Dis. 1978 Dec;54(6):403-8. doi: 10.1136/sti.54.6.403.
4
The significance of the ipazyme IgA and IgG antibody test in the diagnosis of urogenital chlamydial infections.
Zentralbl Bakteriol Mikrobiol Hyg A. 1989 Jan;270(3):373-8. doi: 10.1016/s0176-6724(89)80005-7.
5
Interpretation of Chlamydia trachomatis antibody response in chlamydial oculogenital infection.
Genitourin Med. 1995 Apr;71(2):94-7. doi: 10.1136/sti.71.2.94.
6
Antibodies to Chlamydia trachomatis in acute salpingitis.
Br J Vener Dis. 1979 Feb;55(1):26-9. doi: 10.1136/sti.55.1.26.
7
Chlamydial serum IgG, IgA and local IgA antibodies in patients with genital-tract infections measured by solid-phase radioimmunoassay.
J Med Microbiol. 1981 Feb;14(1):77-87. doi: 10.1099/00222615-14-1-77.
8
Serological studies in Chlamydia trachomatis associated pneumonia of infants.
Acta Microbiol Hung. 1986;33(1):51-4.
9
Significance of immunoglobulin A titres in the diagnosis of urogenital chlamydial infections.
Eur J Clin Microbiol Infect Dis. 1989 Aug;8(8):726-8. doi: 10.1007/BF01963761.
10
Diagnostic efficacy of chlamydial antibodies in cervical secretions from pregnant women and adolescent girls.
Genitourin Med. 1995 Dec;71(6):370-4. doi: 10.1136/sti.71.6.370.
引用本文的文献
1
Evaluation of two nonculture antigen tests and three serotests for detection of anti-chlamydial antibodies in the diagnosis of ocular chlamydial infections.
Graefes Arch Clin Exp Ophthalmol. 1996 Aug;234(8):510-4. doi: 10.1007/BF00184860.
2
Diagnostic efficacy of chlamydial antibodies in cervical secretions from pregnant women and adolescent girls.
Genitourin Med. 1995 Dec;71(6):370-4. doi: 10.1136/sti.71.6.370.
3
Chlamydial serology in genital infections: ImmunoComb versus Ipazyme.
Infection. 1993 Nov-Dec;21(6):384-9. doi: 10.1007/BF01728919.
4
Chlamydia trachomatis species specific serology: ImmunoComb Chlamydia bivalent versus microimmunofluorescence (MIF).
Infection. 1994 May-Jun;22(3):165-73. doi: 10.1007/BF01716696.
5
Enzyme immunoassay with enhanced specificity for detection of antibodies to Chlamydia trachomatis.
J Clin Microbiol. 1994 Jun;32(6):1419-26. doi: 10.1128/jcm.32.6.1419-1426.1994.
6
Chlamydia trachomatis: serological diagnosis.
Infection. 1982;10 Suppl 1:S25-31. doi: 10.1007/BF01640711.
7
Chlamydial antigens stabilized with formalin for use in the micro-immunofluorescence test.
J Clin Microbiol. 1980 Sep;12(3):409-12. doi: 10.1128/jcm.12.3.409-412.1980.
8
Screening for chlamydial infections in women attending family planning clinics.
West J Med. 1983 Mar;138(3):375-9.
9
Immune response in mice infected in the genital tract with mouse pneumonitis agent (Chlamydia trachomatis biovar).
Infect Immun. 1984 Apr;44(1):82-5. doi: 10.1128/iai.44.1.82-85.1984.
10
Serotypes of antibodies against chlamydiae.
Br J Vener Dis. 1983 Oct;59(5):341. doi: 10.1136/sti.59.5.341-a.
本文引用的文献
1
Predictive value of a single diagnostic test in unselected populations.
N Engl J Med. 1966 May 26;274(21):1171-3. doi: 10.1056/NEJM196605262742104.
2
Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test.
Am J Ophthalmol. 1970 Sep;70(3):367-74. doi: 10.1016/0002-9394(70)90096-6.
3
Fluorescent antibody responses to chlamydial infection in patients with lymphogranuloma venereum and urethritis.
J Immunol. 1974 Jun;112(6):2126-34.
4
Antibodies to TRIC agents in tears and serum of naturally infected humans.
J Infect Dis. 1973 Jan;127(1):95-8. doi: 10.1093/infdis/127.1.95.
5
Simplified microimmunofluorescence test with trachoma-lymphogranuloma venereum (Chlamydia trachomatis) antigens for use as a screening test for antibody.
J Clin Microbiol. 1975 Mar;1(3):250-5. doi: 10.1128/jcm.1.3.250-255.1975.
6
Genital chlamydial infections.
Am J Epidemiol. 1976 May;103(5):428-35. doi: 10.1093/oxfordjournals.aje.a112243.
7
Chlamydiae, cervicitis, and abnormal Papanicolaou smears.
Obstet Gynecol. 1979 Jan;53(1):27-30.
8
Fifteen-month follow-up study of women infected with Chlamydia trachomatis.
N Engl J Med. 1979 Jan 18;300(3):123-5. doi: 10.1056/NEJM197901183000305.
9
Gonococcal serology: how soon, how useful, and how much.
J Infect Dis. 1977 Feb;135(2):330-4. doi: 10.1093/infdis/135.2.330.
10
Rapid diagnosis of chlamydial infection of the cervix.
Br J Vener Dis. 1978 Dec;54(6):403-8. doi: 10.1136/sti.54.6.403.
Zotero 插件