血清学在诊断女性生殖道衣原体感染中的失效情况。
Failure of serology in diagnosing chlamydial infections of the female genital tract.
作者信息
Schachter J, Cles L, Ray R, Hines P A
出版信息
J Clin Microbiol. 1979 Nov;10(5):647-9. doi: 10.1128/jcm.10.5.647-649.1979.
Abstract
Chlamydia trachomatis was recoved from 20% (36/180) of women attending a venereal disease clinic. All infected women had chlamydial antibodies in their serum and cervical secretions. However, the background rates of chlamydial antibody in chlamydia-negative women were very high. Measurement of antibodies in serum (complement fixation or immunoglobulin G [IgG] and IgM by microimmunofluorescence) or cervical secretion (IgG, IgM, IgA or secretory IgA classes) did not result in predictive values of greater than 32%. It is concluded that the detection of chlamydial antibodies in serum or cervical secretions cannot be substituted for agent isolation in diagnosing these infections.
摘要
从一家性病诊所就诊的女性中，20%（36/180）检出沙眼衣原体。所有感染女性的血清和宫颈分泌物中均有衣原体抗体。然而，衣原体阴性女性中衣原体抗体的背景率非常高。检测血清中的抗体（补体结合试验或用微量免疫荧光法检测免疫球蛋白G[IgG]和IgM）或宫颈分泌物中的抗体（IgG、IgM、IgA或分泌型IgA类别），预测值均未超过32%。结论是，在诊断这些感染时，血清或宫颈分泌物中衣原体抗体的检测不能替代病原体分离。
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本文引用的文献
1
Predictive value of a single diagnostic test in unselected populations.未经过筛选的人群中单一诊断测试的预测价值。
N Engl J Med. 1966 May 26;274(21):1171-3. doi: 10.1056/NEJM196605262742104.
2
Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test.新型微量滴定间接免疫荧光试验中生殖系统沙眼衣原体、性病性淋巴肉芽肿及相关病原体之间的免疫学关系
Am J Ophthalmol. 1970 Sep;70(3):367-74. doi: 10.1016/0002-9394(70)90096-6.
3
Fluorescent antibody responses to chlamydial infection in patients with lymphogranuloma venereum and urethritis.性病性淋巴肉芽肿和尿道炎患者对衣原体感染的荧光抗体反应。
J Immunol. 1974 Jun;112(6):2126-34.
4
Antibodies to TRIC agents in tears and serum of naturally infected humans.
J Infect Dis. 1973 Jan;127(1):95-8. doi: 10.1093/infdis/127.1.95.
5
Simplified microimmunofluorescence test with trachoma-lymphogranuloma venereum (Chlamydia trachomatis) antigens for use as a screening test for antibody.采用沙眼 - 性病性淋巴肉芽肿（沙眼衣原体）抗原的简易微量免疫荧光试验，用作抗体筛查试验。
J Clin Microbiol. 1975 Mar;1(3):250-5. doi: 10.1128/jcm.1.3.250-255.1975.
6
Genital chlamydial infections.
Am J Epidemiol. 1976 May;103(5):428-35. doi: 10.1093/oxfordjournals.aje.a112243.
7
Chlamydiae, cervicitis, and abnormal Papanicolaou smears.
Obstet Gynecol. 1979 Jan;53(1):27-30.
8
Fifteen-month follow-up study of women infected with Chlamydia trachomatis.
N Engl J Med. 1979 Jan 18;300(3):123-5. doi: 10.1056/NEJM197901183000305.
9
Gonococcal serology: how soon, how useful, and how much.
J Infect Dis. 1977 Feb;135(2):330-4. doi: 10.1093/infdis/135.2.330.
10
Rapid diagnosis of chlamydial infection of the cervix.宫颈衣原体感染的快速诊断
Br J Vener Dis. 1978 Dec;54(6):403-8. doi: 10.1136/sti.54.6.403.
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