Hijjawi Nawal, Tout Faten S, Azaizeh Baraah, Aljaafreh Baraah
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Clin Rheumatol. 2025 Feb;44(2):591-600. doi: 10.1007/s10067-024-07285-9. Epub 2024 Dec 26.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by joint inflammation and destruction. Recent studies emphasize the importance of vitamins D, B12, C, and K in managing RA and enhancing patient health. Vitamin D deficiency is common in RA patients and correlates with increased disease severity, indicating its potential to modulate immune responses and reduce inflammation. Supplementation has shown promise in improving disease activity scores and lowering inflammatory markers. Vitamin B12 is vital for energy and neurological function; its deficiency can worsen fatigue in RA sufferers. Vitamin C, with its antioxidant properties, aids collagen synthesis and may reduce joint inflammation. Vitamin K, particularly through Matrix Gla-Protein (MGP), is essential for bone health and may help prevent joint calcification and osteoporosis. Collectively, these vitamins play critical roles in immune modulation, inflammation reduction, and bone health in RA management, warranting further research on optimal dosages and combinations for effective treatment strategies.
类风湿性关节炎（RA）是一种以关节炎症和破坏为特征的慢性自身免疫性疾病。最近的研究强调了维生素D、B12、C和K在管理类风湿性关节炎和增进患者健康方面的重要性。维生素D缺乏在类风湿性关节炎患者中很常见，并且与疾病严重程度增加相关，表明其具有调节免疫反应和减轻炎症的潜力。补充维生素D已显示出改善疾病活动评分和降低炎症标志物的前景。维生素B12对能量和神经功能至关重要；其缺乏会使类风湿性关节炎患者的疲劳加重。具有抗氧化特性的维生素C有助于胶原蛋白合成，并可能减轻关节炎症。维生素K，特别是通过基质Gla蛋白（MGP），对骨骼健康至关重要，可能有助于预防关节钙化和骨质疏松症。总体而言，这些维生素在类风湿性关节炎管理中的免疫调节、炎症减轻和骨骼健康方面发挥着关键作用，需要进一步研究最佳剂量和组合以制定有效的治疗策略。
