Fu Jie, Chen Xiu, Li Jinglun, Peng Lilei
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Front Med (Lausanne). 2025 May 8;12:1569732. doi: 10.3389/fmed.2025.1569732. eCollection 2025.
Sappanone A (SA), a kind of homoisoflavanone extracted from the dry heartwood of , has been shown to possess diverse bioactivities involving anti-inflammatory, antioxidant, and anti-apoptotic properties. Sustained proinflammatory state is a major factor in the occurrence and development of various diseases. Given the characteristics of SA, many studies have explored the effect of SA on inflammation-related diseases, which uncovered the multifaceted therapeutic potential of SA in such diseases. In this mini-review, we summarized the current achievements of SA on inflammation-related diseases (such as myocardial ischemia-reperfusion injury, liver injury, respiratory diseases, and kidney injury, etc.), in order to provide useful insights into the role of SA in inflammation-related diseases and benefit future clinical applications.
苏木酮A（SA）是从[植物名称]干燥心材中提取的一种高异黄酮，已被证明具有多种生物活性，包括抗炎、抗氧化和抗凋亡特性。持续的促炎状态是各种疾病发生和发展的主要因素。鉴于SA的特性，许多研究探讨了SA对炎症相关疾病的影响，揭示了SA在这些疾病中的多方面治疗潜力。在本综述中，我们总结了SA在炎症相关疾病（如心肌缺血再灌注损伤、肝损伤、呼吸系统疾病和肾损伤等）方面的当前研究成果，以便深入了解SA在炎症相关疾病中的作用，并为未来的临床应用提供帮助。
