Luo Bei, Zou Yanxiang, Yan Jiuqi, Sun Jian, Wei Xiang, Chang Lei, Lu Yue, Zhao Liang, Dong Wenwen, Qiu Chang, Yan Jun, Zhang Yanhong, Zhang Wenbin
Department of Functional Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
School of Nursing, Nanjing Medical University, Nanjing, China.
CNS Neurosci Ther. 2024 Dec;30(12):e70184. doi: 10.1111/cns.70184.
Cognitive functions are reduced in Parkinson's disease (PD) patients after deep brain stimulation (DBS) surgery. However, the underlying mechanisms remain unclear. The current study attempted to elucidate whether DBS alters the functional connectivity (FC) pattern of cognitive networks in PD patients.
The study obtained fMRI and cognitive scale data from 37 PD patients before and after the DBS surgery. Seed-based FC analysis helped demonstrate the FC changes of the default mode network (DMN), executive control network (ECN), and dorsal attention network (DAN).
PD patients indicated significant network connectivity decline in DMN [such as in right precuneus, left angular gyrus, and left middle frontal gyrus (MFG)], ECN [such as in left inferior parietal gyrus, left MFG, and left supplementary motor area (SMA)], and DAN [such as in left inferior frontal gyrus and left MFG] post-DBS surgery. The phonemic fluency score was positively associated with the FC value of the right precuneus and left angular gyrus in DMN before DBS.
The general reduction in FC in the major cognitive networks after DBS surgery depicted the presence of the corresponding network reorganization. Further research can help explore the mechanism of impaired cognitive function post-DBS.
帕金森病（PD）患者在接受脑深部电刺激（DBS）手术后认知功能会降低。然而，其潜在机制仍不清楚。本研究试图阐明DBS是否会改变PD患者认知网络的功能连接（FC）模式。
该研究获取了37例PD患者在DBS手术前后的功能磁共振成像（fMRI）和认知量表数据。基于种子点的FC分析有助于证明默认模式网络（DMN）、执行控制网络（ECN）和背侧注意网络（DAN）的FC变化。
PD患者在DBS手术后，DMN（如右侧楔前叶、左侧角回和左侧额中回）、ECN（如左侧顶下小叶、左侧额中回和左侧辅助运动区）和DAN（如左侧额下回和左侧额中回）的网络连接显著下降。在DBS手术前，语音流畅性得分与DMN中右侧楔前叶和左侧角回的FC值呈正相关。
DBS手术后主要认知网络中FC的普遍降低表明存在相应的网络重组。进一步的研究有助于探索DBS术后认知功能受损的机制。
