Pu Xiuxiu, Ye Qiao
Rheumatology and Immunology Department, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Jiaxing University Graduate Joint Training Center, Zhejiang Chinese Medical University, Jiaxing, China.
J Biochem Mol Toxicol. 2025 Jan;39(1):e70096. doi: 10.1002/jbt.70096.
To investigate the role and mechanism of triptophenolide (TRI) in resisting rheumatoid arthritis (RA). Network pharmacology analysis results suggested that TRI was related to multiple inflammation-related signaling proteins, and possessed the stable structural configuration. In animal experiments, TRI suppressed RA in mice, inhibited tissue inflammation, and improved synovial injury. Moreover, TRI can suppress RA via multiple signaling pathways, and inhibiting pyroptosis is one of the feasible treatments for improving RA.
探讨雷公藤甲素（TRI）抗类风湿关节炎（RA）的作用及机制。网络药理学分析结果表明，TRI与多种炎症相关信号蛋白有关，且具有稳定的结构构型。在动物实验中，TRI可抑制小鼠的RA，减轻组织炎症，改善滑膜损伤。此外，TRI可通过多种信号通路抑制RA，抑制细胞焦亡是改善RA的可行治疗方法之一。
