Xu Peng, He Yucheng, Wang Junyi, Sheng Yingkun, Wang Jianfeng
College of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Xingzhi College, Zhejiang Normal University, Jinhua 321004, China.
Foods. 2025 Sep 6;14(17):3121. doi: 10.3390/foods14173121.
The rapid rise in obesity has evolved into a critical global public health concern. Considering the potential adverse effects of current anti-obesity medications, the development of functional foods sourced from natural materials has emerged as a viable alternative. Blueberries, a category of berry fruits, exhibit potential anti-obesity characteristics. In this research, we assessed the impacts of Blueberry extract rich in anthocyanins (BE) on lipid metabolism and liver health in a high-fat diet (HFD)-induced obese mouse model. The findings indicated that BE notably diminished lipid accumulation in both serum and the liver, and mitigated hepatic steatosis and oxidative stress. Integrated proteomic, metagenomic, and metabolomic analyses further revealed the underlying mechanisms. Consumption of BE intake reconfigured the gut microbiota composition and reduced the microbial capacity for secondary bile acid metabolism, thereby interrupting bile acid recycling and facilitating fecal excretion. This process led to a reduction in systemic cholesterol levels and ultimately alleviated hepatic lipid accumulation, resulting in enhanced liver health.
肥胖率的迅速上升已演变成一个至关重要的全球公共卫生问题。考虑到当前抗肥胖药物的潜在不良影响，开发源自天然材料的功能性食品已成为一种可行的替代方案。蓝莓，作为浆果类水果的一种，具有潜在的抗肥胖特性。在本研究中，我们评估了富含花青素的蓝莓提取物（BE）对高脂饮食（HFD）诱导的肥胖小鼠模型中脂质代谢和肝脏健康的影响。研究结果表明，BE显著减少了血清和肝脏中的脂质积累，并减轻了肝脏脂肪变性和氧化应激。综合蛋白质组学、宏基因组学和代谢组学分析进一步揭示了其潜在机制。摄入BE重新配置了肠道微生物群组成，并降低了微生物对次级胆汁酸代谢的能力，从而中断了胆汁酸循环并促进粪便排泄。这一过程导致全身胆固醇水平降低，最终减轻了肝脏脂质积累，从而改善了肝脏健康。
