Xiao Yuxuan, Bi Xianru, Zhang Rongjie, Li Yu, Sun Wei, Hao Yingxue
Department of Vascular Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
College of Bioengineering, Chongqing University, Chongqing, China.
Clin Exp Hypertens. 2025 Dec;47(1):2440342. doi: 10.1080/10641963.2024.2440342. Epub 2024 Dec 26.
This study investigated the impact of maternal high-fat diet on vascular function and endothelial homeostasis in offspring. We found that offspring exposed to maternal high-fat diet exhibited elevated blood pressure, impaired abdominal aortic vascular function, and endothelial homeostasis imbalance. These changes were accompanied by increased levels of reactive oxygen species (ROS) and upregulation of pro-inflammatory cytokines (including IL-1β, TNF-α, IL-6, and IL-10). Treatment with NLRP3 or IL-1β inhibitors prevented the deterioration in vascular function, reduced endothelial NO production, and inflammation induced by maternal high-fat diet exposure compared to the control group. The findings suggest that during pregnancy, mitigating the vascular impairments in offspring induced by maternal high-fat diet can be achieved by inhibiting the NLRP3/IL-1β pathway.
本研究调查了母体高脂饮食对后代血管功能和内皮稳态的影响。我们发现，暴露于母体高脂饮食的后代表现出血压升高、腹主动脉血管功能受损以及内皮稳态失衡。这些变化伴随着活性氧（ROS）水平的升高和促炎细胞因子（包括IL-1β、TNF-α、IL-6和IL-10）的上调。与对照组相比，用NLRP3或IL-1β抑制剂治疗可预防母体高脂饮食暴露引起的血管功能恶化、减少内皮一氧化氮生成和炎症。研究结果表明，在怀孕期间，通过抑制NLRP3/IL-1β途径可以减轻母体高脂饮食诱导的后代血管损伤。
