Das Samprita, Manor Uri
Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
Front Neurol. 2024 Dec 11;15:1511938. doi: 10.3389/fneur.2024.1511938. eCollection 2024.
Hearing loss can profoundly impact an individual's quality of life, affecting communication, social interactions, and overall well-being. Many people with hearing impairment report feelings of isolation, frustration, and decreased confidence in social settings, which can lead to withdrawal from activities they once enjoyed. Genetics plays a significant role in congenital hearing loss, accounting for approximately half of all cases. While gene therapy holds immense promise for restoring hearing function in cases of hereditary hearing loss (HHL), current methods face certain challenges that must be overcome to successfully develop therapeutic approaches. This review will explore these challenges and offer a perspective on how epigenetic modulation has the potential to address them, potentially revolutionizing the treatment of genetic hearing disorders.
听力损失会对个人生活质量产生深远影响，影响沟通、社交互动和整体幸福感。许多听力受损的人报告说，在社交场合中会感到孤立、沮丧，自信心下降，这可能导致他们退出曾经喜欢的活动。遗传学在先天性听力损失中起着重要作用，约占所有病例的一半。虽然基因疗法在恢复遗传性听力损失（HHL）病例的听力功能方面具有巨大潜力，但目前的方法面临一些必须克服的挑战，才能成功开发出治疗方法。本综述将探讨这些挑战，并就表观遗传调控如何有潜力解决这些挑战提供一个观点，这可能会彻底改变遗传性听力障碍的治疗方法。
