Gorczyca-Głowacka Iwona, Kołomańska Magdalena, Mazurkiewicz Robert, Niżnik Marcin, Ratnicki Krzysztof, Czerniak Małgorzata, Myrcha Piotr, Lenarcik Sebastian, Mitura Kryspin, Kacprzak Laura, Pajer Małgorzata, Richter Piotr, Rapacz Kamil, Sroczyński Maciej, Szmit Mateusz, Nawacki Łukasz
Collegium Medicum, The Jan Kochanowski University, 25-317 Kielce, Poland.
Independent Public Healthcare Center of the Ministry of Interior and Administration, 80-104 Gdansk, Poland.
J Clin Med. 2025 Aug 31;14(17):6158. doi: 10.3390/jcm14176158.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by the presence of hepatic steatosis and at least one cardiometabolic risk factor. Differences in the incidence of MASLD between men and women are primarily due to distinct metabolic and cardiovascular profiles. The aim of this observational study was to investigate the prevalence and characteristics of MASLD in men and women. The study included patients from the Polish Gallstone Surgery Registry diagnosed with MASLD according to current criteria. Among 3419 patients, MASLD was diagnosed in 24.2%. Its prevalence was significantly higher in men (29.8%) than in women (21.9%) ( < 0.0001), with the highest incidence observed in men aged 70-79 (32.1%) and women aged 70-79 (33.3%). MASLD was associated with overweight in individuals aged < 50 years (OR 1.87; 95% CI: 1.11-3.14; < 0.0186) and in those aged ≥ 50 years (OR 1.99; 95% CI: 1.48-2.68; < 0.001), as well as with obesity in patients aged < 50 years (OR 6.53; 95% CI: 4.08-10.47; < 0.001) and in those aged ≥ 50 years (OR 3.9; 95% CI: 2.92-5.22; < 0.0001). In this study, MASLD was diagnosed more frequently in men than in women, and its incidence showed a positive association with increasing BMI. These findings indicate that excess body weight and sex are key predictors of MASLD, highlighting the need for individualized treatment strategies.
代谢功能障碍相关脂肪性肝病（MASLD）的定义是存在肝脂肪变性和至少一种心血管代谢风险因素。男性和女性MASLD发病率的差异主要归因于不同的代谢和心血管特征。这项观察性研究的目的是调查男性和女性中MASLD的患病率及特征。该研究纳入了波兰胆结石手术登记处中根据现行标准诊断为MASLD的患者。在3419名患者中，24.2%被诊断为MASLD。其患病率在男性中（29.8%）显著高于女性（21.9%）（P<0.0001），在70 - 79岁男性中发病率最高（32.1%），在70 - 79岁女性中发病率最高（33.3%）。MASLD与年龄<50岁的个体超重相关（OR 1.87；95%CI：1.11 - 3.14；P<0.0186）以及年龄≥50岁的个体超重相关（OR 1.99；95%CI：1.48 - 2.68；P<0.001），还与年龄<50岁的患者肥胖相关（OR 6.53；95%CI：4.08 - 10.47；P<0.001）以及年龄≥50岁的患者肥胖相关（OR 3.9；95%CI：2.92 - 5.22；P<0.0001）。在本研究中，MASLD在男性中的诊断频率高于女性，且其发病率与BMI升高呈正相关。这些发现表明，超重和性别是MASLD的关键预测因素，突出了个性化治疗策略的必要性。
