甲状腺激素敏感性与颈动脉斑块风险之间的关联：一项基于健康体检队列的研究。

Association between thyroid hormone sensitivity and carotid plaque risk: a health examination cohort-based study.

作者信息

Gong Rui, Wang Shi, Ding Hongqiong, Yu Lixia, Xu Ming, Xu Sanping, Ling Yan

机构信息

Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Front Endocrinol (Lausanne). 2024 Dec 11;15:1472752. doi: 10.3389/fendo.2024.1472752. eCollection 2024.

DOI:10.3389/fendo.2024.1472752

PMID:39722809

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11668592/

Abstract

INTRODUCTION

The involvement of thyroid hormone in cardiovascular disease remains debated. The aim of our research was to ascertain whether thyroid hormone sensitivity indices are related to carotid plaque (CAP) risk in the general population.

METHODS

We recruited 5,360 participants for health examinations to explore the correlation between thyroid hormone sensitivity indices and CAP risk. We then compared baseline characteristics of participants with CAP to those without CAP based on multivariate logistic regression analysis. Additionally, we conducted subgroup analyses stratified by gender and age to further elucidate this relationship.

RESULTS

Among the 5,360 participants, 1,055 (19.7%) were diagnosed with CAP. After adjusting for various confounding factors, our results showed a positive association between CAP risk and the indices (TFQI, PTFQI, TSHI, and TT4RI). Conversely, the FT3/FT4 ratio showed a negative correlation with CAP risk. Sex-based subgroup analysis revealed a stronger correlation between thyroid hormone sensitivity and CAP in females compared to males. In the age subgroup, the significant association was observed in older individuals (age >60) compared to middle-aged participants (age ≤60).

CONCLUSION

Our study suggests a significant correlation between thyroid hormone sensitivity and CAP, particularly in females and participants over the age of 60.

摘要

引言

甲状腺激素在心血管疾病中的作用仍存在争议。我们研究的目的是确定甲状腺激素敏感性指标是否与普通人群的颈动脉斑块（CAP）风险相关。

方法

我们招募了5360名参与者进行健康检查，以探讨甲状腺激素敏感性指标与CAP风险之间的相关性。然后，基于多因素逻辑回归分析，我们比较了有CAP和无CAP参与者的基线特征。此外，我们按性别和年龄进行了亚组分析，以进一步阐明这种关系。

结果

在5360名参与者中，1055名（19.7%）被诊断为患有CAP。在调整了各种混杂因素后，我们的结果显示CAP风险与这些指标（TFQI、PTFQI、TSHI和TT4RI）之间存在正相关。相反，FT3/FT4比值与CAP风险呈负相关。基于性别的亚组分析显示，与男性相比，女性中甲状腺激素敏感性与CAP之间的相关性更强。在年龄亚组中，与中年参与者（年龄≤60岁）相比，在老年个体（年龄>60岁）中观察到显著相关性。