Lan Changxin, Guan Yichun, Luo Haining, Ma Xiaoling, Yang Yihua, Bao Hongchu, Hao Cuifang, He Xiaojin, Zhang Han, Gao Ning, Lin Weinan, Ren Mengyuan, Wu Tianxiang, Wang Chao, Ni Xiaoqing, Shen Chunyan, Zhang Jianrui, Ma Junfang, Zhang Rui, Bi Yin, Zhuang Lili, Miao Ruichao, Song Ziyi, An Tong, Liu Zhengteng, Pan Bo, Fang Mingliang, Liu Jing, Bai Zhipeng, Meng Fangang, Chen Yuanchen, Lu Xiaoxia, Guo Yuming, Cao Yunxia, Lu Qun, Wang Bin
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing 100191, China.
Environ Health (Wash). 2024 Oct 21;2(12):918-928. doi: 10.1021/envhealth.4c00107. eCollection 2024 Dec 20.
The adverse effect of ambient PM exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM exposure on the VEP using the fertilization and embryo transfer platform and high-resolution PM data in China. We first investigated the association between PM exposure 1 week before and 1 week after the embryo transfer date and VEP. The average PM concentrations of the 2 weeks were approximately 47 μg/m. The pooled results revealed a negative association between women's accumulated PM exposure during the 2 weeks near the day of embryo transfer and success odds of VEP with the relative risk of 0.999 (95% CI: 0.997-0.999) at each increase of 10 μg/m. The women with the fresh cycle or one transplanted embryo were considered as a vulnerable population. Furthermore, seven periods for the fresh cycle and five periods for the frozen cycle from 85 days before oocyte retrieval to the day of gestational sac detection by ultrasound detection were defined. For these exposure periods, no association between the average PM exposure and VEP risk was identified. Our study provided large-scale population evidence for the association between PM exposure near embryo transfer day and VEP and identified vulnerable populations among women undergoing fertilization-embryo transfer.
环境细颗粒物（PM）暴露对极早期妊娠（VEP）的不良影响在流行病学研究中仍存在争议，但有毒理学证据支持。我们采用了一个包含141,040个周期的多中心回顾性队列，利用中国的受精和胚胎移植平台以及高分辨率PM数据来评估PM暴露对VEP的影响。我们首先研究了胚胎移植日期前1周和后1周的PM暴露与VEP之间的关联。这两周的平均PM浓度约为47μg/m³。汇总结果显示，在胚胎移植日附近的两周内，女性累积的PM暴露与VEP成功几率之间呈负相关，每增加10μg/m³，相对风险为0.999（95%置信区间：0.997 - 0.999）。进行新鲜周期移植或移植一个胚胎的女性被视为脆弱人群。此外，定义了从取卵前85天到超声检测到妊娠囊之日的新鲜周期的七个时间段和冷冻周期的五个时间段。对于这些暴露时间段，未发现平均PM暴露与VEP风险之间存在关联。我们的研究为胚胎移植日附近的PM暴露与VEP之间的关联提供了大规模人群证据，并确定了接受受精 - 胚胎移植的女性中的脆弱人群。
