Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Engineering Laboratory of Preimplantation Genetic Diagnosis and Screening, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Engineering Laboratory of Preimplantation Genetic Diagnosis and Screening, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Environ Toxicol Pharmacol. 2022 Feb;90:103807. doi: 10.1016/j.etap.2021.103807. Epub 2022 Jan 4.
With the acceleration of China's urbanization and industrialization, air pollution has become a major environmental problem. Retrospective data analysis of 6564 patients who underwent IVF-ET in the center for reproductive medicine of the First Affiliated Hospital of Zhengzhou University from 2015 to 2020. Different stages were selected from 90 days before oocyte retrieval to 35 days after transfer and divided into five exposure periods. Multivariate logistic regression was used to analyze the relationship between six ambient air pollutants (PM, PM, NO, SO, CO and O) and the IVF-ET pregnancy outcome. The results showed that air pollutants can significantly affect the IVF pregnancy outcome. The harmful effects of ambient air pollutants are more obvious in the patients aged < 35 years, single embryo transfer and cleavage stage embryo transfer.
随着中国城市化和工业化的加速，空气污染已成为一个主要的环境问题。对 2015 年至 2020 年在郑州大学第一附属医院生殖医学中心接受体外受精-胚胎移植（IVF-ET）的 6564 名患者的回顾性数据分析。从取卵前 90 天到移植后 35 天，选择不同阶段，分为五个暴露期。采用多变量逻辑回归分析了六种环境空气污染物（PM、PM、NO、SO、CO 和 O）与 IVF-ET 妊娠结局的关系。结果表明，空气污染物会显著影响 IVF 妊娠结局。在年龄<35 岁、单胚胎移植和卵裂期胚胎移植的患者中，环境空气污染物的有害影响更为明显。
