Wei Xianping, Zhang Na, Zhu Qingqing, Hu Yu, Wang Xin, Weng Xueyu, Liao Chunyang, Jiang Guibin
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Environ Health (Wash). 2024 Sep 3;2(12):902-911. doi: 10.1021/envhealth.4c00040. eCollection 2024 Dec 20.
Parabens (PBs) and their metabolites (MBs), triclocarban (TCC), triclosan (TCS), bisphenols (BPs), benzophenones (BzPs), and phthalate metabolites (mPAEs) are typical endocrine-disrupting chemicals (EDCs) used in industrial production and daily life. Studies have suggested that these EDCs affect the reproductive system and may cause infertility; however, epidemiological evidence linking EDC exposure to infertility is still lacking. Herein, a total of 302 serum samples from women of reproductive age were collected, and six categories of typical EDCs were analyzed. The results revealed that EDCs are ubiquitous in female serum. The geometric mean (GM) concentrations of ∑PBs, ∑MBs, ∑(TCS+TCC), ∑BPs, ∑BzPs, and ∑mPAEs were 3.36, 297, 3.87, 4.39, 0.257, and 4.56 ng/mL, respectively. The serum concentrations of ∑PBs, ∑MBs, ∑(TCS+TCC), and ∑mPAEs from infertile women (GM: 4.16, 397, 4.01, and 7.33, respectively) were higher than those from fertile women (2.45, 192, 3.65, and 2.27, respectively) ( < 0.05). The results of binary logistic regression and random forest suggest that mPAEs, such as mBP/miBP and mEHP, may contribute to infertility. This study provides insight into the relationship between the EDC exposure and reproductive outcomes.
对羟基苯甲酸酯（PBs）及其代谢物（MBs）、三氯生（TCC）、三氯卡班（TCS）、双酚类（BPs）、二苯甲酮类（BzPs）和邻苯二甲酸酯代谢物（mPAEs）是工业生产和日常生活中使用的典型内分泌干扰化学物质（EDCs）。研究表明，这些EDCs会影响生殖系统并可能导致不孕；然而，将EDC暴露与不孕联系起来的流行病学证据仍然缺乏。在此，共收集了302份育龄女性的血清样本，并分析了六类典型的EDCs。结果显示，EDCs在女性血清中普遍存在。∑PBs、∑MBs、∑（TCS+TCC）、∑BPs、∑BzPs和∑mPAEs的几何平均（GM）浓度分别为3.36、297、3.87、4.39、0.257和4.56 ng/mL。不孕女性的∑PBs、∑MBs、∑（TCS+TCC）和∑mPAEs血清浓度（GM分别为4.16、397、4.01和7.33）高于生育女性（分别为2.45、192、3.65和2.27）（<0.05）。二元逻辑回归和随机森林分析结果表明，mPAEs，如mBP/miBP和mEHP，可能与不孕有关。本研究为EDC暴露与生殖结局之间的关系提供了见解。
