中国大学生尿液和室内灰尘中对羟基苯甲酸酯、二苯甲酮型紫外线滤光剂、三氯生和三氯卡班的分布特征及其对人体暴露的影响。
Profiles of parabens, benzophenone-type ultraviolet filters, triclosan, and triclocarban in paired urine and indoor dust samples from Chinese university students: Implications for human exposure.
机构信息
Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, Guangdong, PR China; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, 510632, Guangdong, PR China.
Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, Guangdong, PR China.
出版信息
Sci Total Environ. 2021 Dec 1;798:149275. doi: 10.1016/j.scitotenv.2021.149275. Epub 2021 Jul 27.
Parabens, benzophenone (BP)-type UV filters, triclosan (TCS), and triclocarban (TCC) are commonly used in personal care products. Human exposure to these compounds has received increasing concern because of their adverse health effects. However, the levels of these chemicals in paired urine and indoor samples have never been simultaneously measured. In this work, eight parabens, eight BP-type UV filters, TCS, and TCC were measured in paired urine and indoor dust samples collected from university students and their dormitories in South China. The target analytes were commonly measured in urine (71%-100%) and indoor dust (30%-98%), with median concentrations ranging from 0.16 ng/mL to 19.3 ng/mL in urine and from <0.01 ng/g to 3700 ng/g in indoor dust samples. Females had high levels of most of these target compounds, and gender-related differences were found in the levels of most target analytes. Positive correlations were found in the levels of methylparaben, ethyl paraben, benzophenone-3, and TCS between urine and indoor dust samples. This finding suggested that indoor dust is an important source for human exposure to these compounds. The estimated daily intake (EDI) of these analytes in paired samples was also evaluated. The median EDI values of target analytes varied in the range of 4.02-59,280 ng/kg bw/day. Females had higher median EDI values for most of target analytes than males. In addition, the median EDI values of most target analytes in dust from female dormitories were higher than those in dust from male dormitories. Indoor dust ingestion only had minor contribution (<0.5%) to the total exposure. To the best of the authors' knowledge, this study is the first to simultaneously analyze the concentrations of parabens, BP-type UV filters, TCS, and TCC in the paired urine and indoor samples from university students in South China.
对羟基苯甲酸酯、二苯甲酮（BP）型紫外线滤光剂、三氯生（TCS）和三氯卡班（TCC）是个人护理产品中常用的物质。由于这些化合物对健康有不良影响，人类接触这些化合物的情况受到了越来越多的关注。然而，这些化学物质在尿液和室内样本中的水平从未同时进行过测量。在这项工作中，我们测量了华南大学生及其宿舍的尿液和室内灰尘样本中的 8 种对羟基苯甲酸酯、8 种 BP 型紫外线滤光剂、TCS 和 TCC。目标分析物在尿液中的检测率为 71%-100%，在室内灰尘中的检测率为 30%-98%，尿液中的中位数浓度范围为 0.16ng/ml 至 19.3ng/ml，室内灰尘中的中位数浓度范围为 <0.01ng/g 至 3700ng/g。女性体内大多数这些目标化合物的含量都较高，且在大多数目标分析物的水平上存在性别差异。尿液和室内灰尘样本中甲基对羟基苯甲酸酯、乙基对羟基苯甲酸酯、二苯甲酮-3 和 TCS 的水平之间存在正相关关系。这一发现表明室内灰尘是人类接触这些化合物的一个重要来源。我们还评估了配对样本中这些分析物的估计日摄入量（EDI）。目标分析物的 EDI 值中位数范围为 4.02-59,280ng/kgbw/day。女性的大多数目标分析物的 EDI 值中位数都高于男性。此外，女性宿舍室内灰尘中大多数目标分析物的 EDI 值中位数高于男性宿舍室内灰尘中的 EDI 值中位数。室内灰尘摄入对总暴露量的贡献较小（<0.5%）。据作者所知，这是首次同时分析华南大学生尿液和室内样本中对羟基苯甲酸酯、BP 型紫外线滤光剂、TCS 和 TCC 的浓度。
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