Mahajan Ankit, Pawar Madhura, Tomer Geetika, Girish P V, Salama Mohamed Tharwat, Dupare Aditya Sudhakar
Department of Dentistry, Government Medical College and Hospital, Kathua, Jammu and Kashmir, India.
Department of Pediatric and Preventive Dentistry Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India.
J Family Med Prim Care. 2024 Nov;13(11):5166-5170. doi: 10.4103/jfmpc.jfmpc_823_24. Epub 2024 Nov 18.
Thalassemia is a hemoglobinopathy-associated genetic disease resulting due to defective synthesis of globin chains, causing defects in the skeletal and oral structures.
This cross-sectional study was designed to analyze the prevalence of dental caries, oral health status, malocclusion status, and dental treatment needs in thalassemic children.
Institutional Ethical committee clearance was obtained before starting the study. The study sample comprised 100 thalassemic and 100 normal children in which oral disease markers like dmft/DMFT index, plaque index, gingival index, and Angle's classification for malocclusion were used. The statistical tool used was 'one-way ANOVA' with the probability set at 0.05.
Statistically significant differences in prevalence of dental caries, periodontal disease, malocclusion, and treatment needs were noted in thalassemic individuals when compared to normal subjects.
The present study has given an insight into the various oral and dentomaxillofacial manifestations of thalassemia, thus considering the importance of routine oral examination for the prevention of dental caries and periodontal diseases.
地中海贫血是一种与血红蛋白病相关的遗传性疾病，由于珠蛋白链合成缺陷所致，会导致骨骼和口腔结构出现缺陷。
本横断面研究旨在分析地中海贫血患儿的龋齿患病率、口腔健康状况、错牙合状况及牙科治疗需求。
在研究开始前获得机构伦理委员会批准。研究样本包括100名地中海贫血患儿和100名正常儿童，使用了如dmft/DMFT指数、菌斑指数、牙龈指数及错牙合的安氏分类等口腔疾病指标。所使用的统计工具为“单因素方差分析”，概率设定为0.05。
与正常受试者相比，地中海贫血患者在龋齿患病率、牙周疾病、错牙合及治疗需求方面存在统计学显著差异。
本研究深入了解了地中海贫血的各种口腔及牙颌面表现，从而认识到常规口腔检查对预防龋齿和牙周疾病的重要性。
