Rahmani Sohrab, Roohbakhsh Ali, Pourbarkhordar Vahid, Karimi Gholamreza
Student Research Committee Mashhad University of Medical Sciences Mashhad Iran.
Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran.
Food Sci Nutr. 2024 Nov 8;12(12):9998-10009. doi: 10.1002/fsn3.4553. eCollection 2024 Dec.
Cardiovascular disease (CVD) poses a major risk to human health and exert a heavy burden on individuals, society, and healthcare systems. Therefore, it is critical to identify CVD's underlying mechanism(s) and target them using effective agents. Natural compounds have shown promise as antioxidants with cardioprotective functions against CVD injuries due to their antioxidative solid capacity and high safety profile. Several CVDs, such as heart failure, ischemia/reperfusion, atherosclerosis, and cardiomyopathies, are closely linked to mitochondrial dysfunction. It is well established that activating the AMPK/SIRT1/PGC-1α pathway during CVD promotes mitochondrial function. Therefore, targeting the AMPK/SIRT1/PGC-1α pathway provides a foundation for novel therapeutic strategies to combat CVD. A key goal of our search was to find natural compounds that target this biological pathway and have beneficial effects on CVD.
心血管疾病（CVD）对人类健康构成重大风险，并给个人、社会和医疗保健系统带来沉重负担。因此，确定CVD的潜在机制并用有效的药物对其进行靶向治疗至关重要。天然化合物因其抗氧化能力强和安全性高，已显示出作为抗氧化剂对CVD损伤具有心脏保护功能的潜力。几种心血管疾病，如心力衰竭、缺血/再灌注、动脉粥样硬化和心肌病，都与线粒体功能障碍密切相关。众所周知，在心血管疾病期间激活AMPK/SIRT1/PGC-1α途径可促进线粒体功能。因此，靶向AMPK/SIRT1/PGC-1α途径为对抗心血管疾病的新型治疗策略提供了基础。我们研究的一个关键目标是找到靶向这一生物学途径并对心血管疾病有有益作用的天然化合物。
