Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmacol Res. 2023 Feb;188:106672. doi: 10.1016/j.phrs.2023.106672. Epub 2023 Jan 20.
Mitochondria are morphologically dynamic organelles frequently undergoing fission and fusion processes that regulate mitochondrial integrity and bioenergetics. These processes are considered critical for cell survival. The mitochondrial fission process regulates mitochondrial biogenesis and mitophagy. It is associated with apoptosis, while mitochondrial fusion controls the accurate distribution of mitochondrial DNA and metabolic substances across the mitochondria. Excessive mitochondrial fission results in mitochondrial structural changes, dysfunction, and cell damage. Accumulating evidence demonstrates that mitochondrial dynamics affect neurodegenerative and cardiovascular diseases along with several other diseases. Biological molecules regulating the process of mitochondrial fission are potential targets for developing therapeutic agents. Many natural products target the dynamin-related protein 1 (Drp1)-dependent mitochondrial fission pathway, and their inhibitory effects ameliorate mitochondrial fragmentation. In this article, we reviewed the research literature that describes Drp1-dependent inhibition as a mechanism for the protective effects of natural compounds.
线粒体是形态上动态的细胞器，经常经历分裂和融合过程，这些过程调节线粒体的完整性和生物能量学。这些过程被认为对细胞存活至关重要。线粒体分裂过程调节线粒体生物发生和线粒体自噬。它与细胞凋亡有关，而线粒体融合控制线粒体 DNA 和代谢物质在整个线粒体中的准确分布。过度的线粒体分裂会导致线粒体结构改变、功能障碍和细胞损伤。越来越多的证据表明，线粒体动力学会影响神经退行性疾病和心血管疾病以及其他几种疾病。调节线粒体分裂过程的生物分子是开发治疗剂的潜在靶点。许多天然产物靶向与动力相关蛋白 1（Drp1）相关的线粒体分裂途径，它们的抑制作用可改善线粒体碎片化。在本文中，我们回顾了描述 Drp1 依赖性抑制作为天然化合物保护作用机制的研究文献。
