Zheng Biaohui, Chen Dongbo, Zeng Hao, Lin Shuangming
Department of Gastrointestinal Surgery, Longyan First Hospital, Longyan, China.
Front Cell Infect Microbiol. 2024 Dec 12;14:1460504. doi: 10.3389/fcimb.2024.1460504. eCollection 2024.
Previous studies have indicated a potential association between gut microbiota and diverticular disease. However, the precise nature of this relationship remains unclear. In light of this, we decided to use a bidirectional two-sample Mendelian randomization (MR) study to investigate the causal relationship between gut microbiota and intestinal diverticular disease in greater depth.
To investigate the potential causal relationship between gut microbiota and intestinal diverticular disease, we conducted a two-sample MR study in a European ancestry. Genetic instrumental variables for gut microbiota were obtained from a genome-wide association study (GWAS) involving 5,959 participants. Summary statistics for intestinal diverticular disease were sourced from the IEU Open GWAS project, which included data from 5,193 cases and 457,740 controls. The analysis was primarily conducted using the inverse variance weighted method, with additional sensitivity analyses to assess the robustness of the findings.
With regard to the findings, 11 microbial taxa were identified as having a potential causal relationship with intestinal diverticular disease. Specifically, the microbial taxa Caryophanales, , , , , and were found to be positively associated with the risk of developing intestinal diverticular disease, while Chromatiales, , , , and were found to be negatively associated with the risk. Further reverse MR analysis did not reveal a reverse causal effect between these microbial taxa and intestinal diverticular disease.
Our MR analyses revealed a potential causal relationship between certain gut microbiota and intestinal diverticular disease, which may provide new directions for future intestinal diverticular disease prevention and treatment strategies.
先前的研究表明肠道微生物群与憩室病之间可能存在关联。然而，这种关系的确切性质仍不清楚。鉴于此，我们决定使用双向两样本孟德尔随机化（MR）研究来更深入地研究肠道微生物群与肠道憩室病之间的因果关系。
为了研究肠道微生物群与肠道憩室病之间的潜在因果关系，我们在欧洲血统人群中进行了一项两样本MR研究。肠道微生物群的遗传工具变量来自一项涉及5959名参与者的全基因组关联研究（GWAS）。肠道憩室病的汇总统计数据来自IEU开放GWAS项目，该项目包括5193例病例和457740例对照的数据。分析主要使用逆方差加权法进行，并进行了额外的敏感性分析以评估研究结果的稳健性。
关于研究结果，11种微生物分类群被确定与肠道憩室病存在潜在因果关系。具体而言，发现Caryophanales、 、 、 、 和 等微生物分类群与患肠道憩室病的风险呈正相关，而Chromatiales、 、 、 和 与风险呈负相关。进一步的反向MR分析未发现这些微生物分类群与肠道憩室病之间存在反向因果效应。
我们的MR分析揭示了某些肠道微生物群与肠道憩室病之间的潜在因果关系这可能为未来肠道憩室病的预防和治疗策略提供新的方向。
