Yi Yuan, Dai Fei, Zhang Yuwen, Han Jiawei, Wei Jialu, Wang Lingbo, Wang He, An Yu
Human Phenome Institute, Institute of Medical Genetics and Genomics, MOE Key Laboratory of Contemporary Anthropology, Zhangjiang Fudan International Innovation Center, Fudan University, 825 Zhangheng Road, Shanghai, 201203 China.
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 201203 China.
Phenomics. 2024 Nov 18;4(5):473-486. doi: 10.1007/s43657-024-00181-x. eCollection 2024 Oct.
() is a neuro-specific gene linked to neurodevelopmental disorders and has recently been reported to function as a bidirectional emotional regulator, highlighting its molecular roles in the nervous system. However, the connections between , brain architecture, and functionality remain to be fully elucidated. Our study utilized 11.7 T multimodal magnetic resonance imaging (MRI) to assess the impact of gene knockout on the brain's microstructure, regional functional activity, and network connectivity during different developmental phases in mice. We observed significant changes in the functional brain network connectivity of mice without marked differences in brain microstructure or regional activity. These changes were particularly pronounced in sensory-related areas, such as the gustatory and auditory systems, in both juvenile and adult specimens. Previous studies have correlated the enhanced Default Mode Network (DMN) with depression, and knockout has been associated with stress resilience. Our findings further revealed reduced connectivity in various DMN regions in adult mice, suggesting a potential link to increased stress tolerance. Moreover, the sensory system's critical role in environmental perception implies that alterations in network connectivity due to knockout could affect the processing and integration of external inputs, thereby influencing emotional experiences.
The online version contains supplementary material available at 10.1007/s43657-024-00181-x.
（）是一种与神经发育障碍相关的神经特异性基因，最近有报道称其作为双向情绪调节因子发挥作用，突显了其在神经系统中的分子作用。然而，（该基因）、脑结构和功能之间的联系仍有待充分阐明。我们的研究利用11.7T多模态磁共振成像（MRI）来评估该基因敲除对小鼠不同发育阶段大脑微观结构、区域功能活动和网络连通性的影响。我们观察到该基因敲除小鼠的功能性脑网络连通性有显著变化，而大脑微观结构或区域活动没有明显差异。这些变化在幼年和成年样本的味觉和听觉系统等感觉相关区域尤为明显。先前的研究已将增强的默认模式网络（DMN）与抑郁症相关联，并且该基因敲除与应激恢复力有关。我们的研究结果进一步揭示成年该基因敲除小鼠的各个DMN区域连通性降低，表明可能与应激耐受性增加有关。此外，感觉系统在环境感知中的关键作用意味着该基因敲除导致的网络连通性改变可能会影响外部输入的处理和整合，从而影响情绪体验。
在线版本包含可在10.1007/s43657-024-00181-x获取的补充材料。
