Sharma Sitara, Brunet Jennifer
School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Cancer Therapeutic Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
J Psychosoc Oncol. 2025;43(3):462-476. doi: 10.1080/07347332.2024.2444276. Epub 2024 Dec 26.
Young adults report challenges concerning cancer--related cognitive impairment (CRCI). This study aimed to: (1) describe cognition in young adults post-cancer treatment using self-report and performance-based measures, and (2) examine associations between cognition and relevant disease-related, psychological, and lifestyle (physical activity; PA) factors.
Forty-six young adults (M = 31.4 ± 5.4 years; 91.3% female) completed web-based questionnaires and neuropsychological tests; data were analyzed via descriptive statistics and bivariate correlations.
Most (60.9%) self-reported clinically meaningful CRCI and displayed poorer executive functioning and processing speed (but not working memory) than normative data. Disease-related factors, psychological factors, and PA had null-to-moderate (s = -0.32-0.28), small-to-large (s = -0.74-0.77), and trivial-to-moderate (s = -0.16 - 0.36) correlations with cognition (respectively), with differences in magnitude between self--reported and objective cognition.
The observed correlations warrant further exploration in larger prospective studies, and trials should investigate causative mechanisms and specific PA parameters.
年轻人报告了与癌症相关的认知障碍（CRCI）方面的挑战。本研究旨在：（1）使用自我报告和基于表现的测量方法描述癌症治疗后年轻人的认知情况，以及（2）研究认知与相关疾病、心理和生活方式（身体活动；PA）因素之间的关联。
46名年轻人（M = 31.4 ± 5.4岁；91.3%为女性）完成了基于网络的问卷调查和神经心理学测试；通过描述性统计和双变量相关性分析数据。
大多数（60.9%）自我报告有临床意义的CRCI，并且与标准数据相比，执行功能和处理速度较差（但工作记忆不差）。疾病相关因素、心理因素和PA与认知的相关性分别为无到中等（s = -0.32 - 0.28）、小到较大（s = -0.74 - 0.77）和微不足道到中等（s = -0.16 - 0.36），自我报告的认知和客观认知在程度上存在差异。
观察到的相关性值得在更大规模的前瞻性研究中进一步探索，并且试验应该研究因果机制和特定的PA参数。
