Pembroke Lorna, Sherman Kerry A, Dhillon Haryana M, Francis Heather, Gillatt David, Gurney Howard
Lifespan Health and Wellbeing Research Centre, Macquarie University, New South Wales, 2109, Australia.
School of Psychological Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University & Macquarie University Hospital, New South Wales, Macquarie, 2109, Australia.
Support Care Cancer. 2025 Aug 2;33(8):744. doi: 10.1007/s00520-025-09771-5.
As more individuals survive prostate cancer, addressing survivorship concerns like cancer-related cognitive impairment (CRCI) becomes increasingly important. Identifying modifiable psychosocial factors related to CRCI is critical in devising targeted non-pharmacological interventions. We aimed to investigate the psychosocial factors associated with perceived cognitive functioning in prostate cancer survivors (PCS).
Adult PCS, either undergoing hormone therapy or on 'watchful waiting'/ 'active surveillance', were recruited for a cross-sectional survey. Perceived cognitive functioning was measured using the Perceived Cognitive Impairments subscale (PCI20) from the Functional Assessment of Cancer Therapy- Cognitive Function questionnaire. Pearson's correlations and ANOVAs explored the association between PCI20 and psychosocial factors including psychological distress, interpersonal functioning, functional well-being, self-compassion and intellectual engagement. Significant variables were included as predictors in a hierarchical regression, examining the relationship with PCI20 and related psychosocial factors while controlling for demographic, biomedical and lifestyle factors.
Of the 96 respondents, one-third reported low cognitive function. Better perceived cognitive functioning was associated with better physical well-being and functional well-being and lower depression levels. In a regression analysis with depression, physical and functional well-being as predictors, only functional well-being was a significant predictor of perceived cognitive functioning after controlling for cancer treatment and levels of physical activity.
Perceived cognitive functioning was associated with self-reported quality of life and the ability to participate in day-to-day activities including work and enjoyment. The use of a biopsychosocial approach in identifying modifiable avenues for therapeutic interventions addressing CRCI may be beneficial.
随着越来越多的人在前列腺癌中存活下来，解决诸如癌症相关认知障碍（CRCI）等生存问题变得越来越重要。识别与CRCI相关的可改变的心理社会因素对于设计有针对性的非药物干预措施至关重要。我们旨在调查前列腺癌幸存者（PCS）中与感知认知功能相关的心理社会因素。
招募正在接受激素治疗或处于“观察等待”/“主动监测”状态的成年PCS进行横断面调查。使用癌症治疗功能评估-认知功能问卷中的感知认知障碍子量表（PCI20）来测量感知认知功能。Pearson相关性分析和方差分析探讨了PCI20与心理社会因素之间的关联，这些因素包括心理困扰、人际功能、功能幸福感、自我同情和智力参与。在分层回归中纳入显著变量作为预测因子，在控制人口统计学、生物医学和生活方式因素的同时，检验与PCI20及相关心理社会因素的关系。
在96名受访者中，三分之一的人报告认知功能较低。更好的感知认知功能与更好的身体健康、功能幸福感以及更低的抑郁水平相关。在以抑郁、身体和功能幸福感作为预测因子的回归分析中，在控制癌症治疗和身体活动水平后，只有功能幸福感是感知认知功能的显著预测因子。
感知认知功能与自我报告的生活质量以及参与包括工作和娱乐在内的日常活动的能力相关。采用生物心理社会方法来确定针对CRCI的可改变的治疗干预途径可能是有益的。
