Plotz R D
Hum Pathol. 1985 Feb;16(2):113-6. doi: 10.1016/s0046-8177(85)80058-7.
The extent of the familial occurrence of hemolytic disease of the newborn due to AO blood group incompatibility between mother and fetus was examined. The records of all families in which the mother had blood group O and two or more babies had blood group A, with one of them having been born at Women & Infants Hospital of Rhode Island in the index year of 1979, were examined. Eighty-nine of these families fulfilled criteria intended to exclude causes of hyperbilirubinemia other than AO blood group incompatibility. The peak bilirubin level in each infant was graded as normal, elevated, or severely elevated. The relations between birth order and peak bilirubin level, between peak bilirubin levels in the first and second babies in each family, and between gestational age and peak bilirubin level were assessed. The first two of these relations showed effects at the 0.10 and 0.05 significance levels, respectively. It is concluded that the risk of hyperbilirubinemia attributable to AO blood group incompatibility is greater for the second than for the first baby at risk in a sibship, that the risk is yet greater for the second if the first was also affected, and that, in the latter case, there is also increased risk of marked hyperbilirubinemia.
研究了因母婴AO血型不合导致新生儿溶血病的家族发病情况。查阅了所有母亲为O型血且有两个或以上婴儿为A型血的家庭记录，其中有一个婴儿于1979年索引年在罗德岛妇女与婴儿医院出生。这些家庭中有89个符合标准，旨在排除除AO血型不合以外的高胆红素血症病因。将每个婴儿的胆红素峰值水平分为正常、升高或严重升高。评估了出生顺序与胆红素峰值水平之间的关系、每个家庭中第一个和第二个婴儿的胆红素峰值水平之间的关系以及胎龄与胆红素峰值水平之间的关系。其中前两个关系分别在0.10和0.05的显著性水平上显示出影响。得出的结论是，在同胞关系中，因AO血型不合导致高胆红素血症的风险，第二个有风险的婴儿比第一个更大；如果第一个婴儿也受到影响，第二个婴儿的风险更大；在后一种情况下，出现明显高胆红素血症的风险也会增加。
